Uzair Bushra, Tabassum Sobia, Rasheed Madiha, Rehman Saima Firdous
Department of Bioinformatics and Biotechnology, International Islamic University Islamabad, Sector H-10, 44000 Islamabad, Pakistan.
ScientificWorldJournal. 2012;2012:179782. doi: 10.1100/2012/179782. Epub 2012 Apr 1.
The Ocean, which is called the "mother of origin of life," is also the source of structurally unique natural products that are mainly accumulated in living organisms. Cyanobacteria are photosynthetic prokaryotes used as food by humans. They are excellent source of vitamins and proteins vital for life. Several of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immunodeficiency syndrome (AIDS), arthritis, and so forth, while other compounds have been developed as analgesics or to treat inflammation, and so forth. They produce a large variety of bioactive compounds, including substances with anticancer and antiviral activity, UV protectants, specific inhibitors of enzymes, and potent hepatotoxins and neurotoxins. Many cyanobacteria produce compounds with potent biological activities. This paper aims to showcase the structural diversity of marine cyanobacterial secondary metabolites with a comprehensive coverage of alkaloids and other applications of cyanobacteria.
被称为“生命起源之母”的海洋，也是结构独特的天然产物的来源，这些天然产物主要积累在生物体内。蓝细菌是作为人类食物的光合原核生物。它们是对生命至关重要的维生素和蛋白质的优质来源。其中一些化合物具有药理活性，有助于生物活性化合物的发明和发现，主要针对癌症、获得性免疫缺陷综合征（艾滋病）、关节炎等致命疾病，而其他化合物已被开发用作镇痛药或治疗炎症等。它们产生各种各样的生物活性化合物，包括具有抗癌和抗病毒活性的物质、紫外线保护剂、酶的特异性抑制剂以及强效肝毒素和神经毒素。许多蓝细菌产生具有强大生物活性的化合物。本文旨在展示海洋蓝细菌次生代谢产物的结构多样性，并全面涵盖生物碱以及蓝细菌的其他应用。
