5%氯硝柳胺乙醇胺盐颗粒剂的制备及其杀螺效果

[Preparation and molluscicidal effect of 5% niclosamide ethanolamine granules].

作者信息

Xing Yun-tian, Dai Jian-rong, Dai Yang, Yang Zhen-kun, Wang Fei, Liang Xiao-tian, Ma Bo, Qu Guo-li, Wang Wei, Liang You-sheng

机构信息

Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory of Molecular Biology of Parasites, Wuxi 14064, China.

Jiangsu Aifin Agrochemical Co., Ltd. China.

出版信息

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2013 Oct;25(5):473-6.

PMID:24490355

Abstract

OBJECTIVE

To explore the preparation of 5% niclosamide ethanolamine granules and evaluate its molluscicidal effect.

METHODS

The optimal formula was obtained by the selection of wetting agents, dispersants, adhesives and carriers. The molluscicidal effect of 5% niclosamide ethanolamine granules was measured by the spray methods in the laboratory and field.

RESULTS

The mixed 5% niclosamide ethanolamine, 0.2% sodium lauryl sulfate, and 1% alkylphenol sulfonic polyxyethylene ether sulfonate were crushed by gas flow, and then mixed with 93.7% quartz sand and 0.1% polyvinyl alcohol water solution, drying to 5% niclosamide ethanolamine granules. The density, bulk density, and moisture of 5% niclosamide ethanolamine granules were 1.4 g/ml, 1.3 g/ml, and 2.4%, respectively, and the hot storage stability was qualified. Under the lab condition, the death rates of Oncomelania hupensis snails sprayed with 0.5 g/m2 (7 d) or 1.0 g/m2 (1 d) of 5% niclosamide ethanolamine granules were higher than 95%. In the field, the death rates of the snails sprayed with 0.5 g/m2 (7 d) or 1.0 g/m2 (1 d) were higher than 85%.

CONCLUSION

There is a high molluscicidal effect of 5% niclosamide ethanolamine granules and it is suitable for field application.

摘要

目的

探索5%氯硝柳胺乙醇胺颗粒剂的制备方法并评价其杀螺效果。

方法

通过对润湿剂、分散剂、黏合剂和载体的筛选获得最佳配方。采用喷雾法在实验室和现场测定5%氯硝柳胺乙醇胺颗粒剂的杀螺效果。

结果

将5%氯硝柳胺乙醇胺、0.2%十二烷基硫酸钠和1%烷基酚聚氧乙烯醚磺酸盐混合后经气流粉碎，再与93.7%石英砂和0.1%聚乙烯醇水溶液混合，干燥制成5%氯硝柳胺乙醇胺颗粒剂。5%氯硝柳胺乙醇胺颗粒剂的堆密度、松密度和水分分别为1.4 g/ml、1.3 g/ml和2.4%，热贮稳定性合格。在实验室条件下，用0.5 g/m²（7天）或1.0 g/m²（1天）的5%氯硝柳胺乙醇胺颗粒剂喷洒钉螺，死亡率高于95%。在现场，用0.5 g/m²（7天）或1.0 g/m²（1天）喷洒钉螺，死亡率高于85%。