乙酰螺旋霉素联合阿奇霉素治疗妊娠期弓形虫感染的临床经验

[Clinical experience on treating Toxoplasma gondii infection during pregnancy by using acetyl spiramycin combined with azithromycin].

作者信息

Tang Hong-xia, Xiong Xue-feng, Qin Zhi-qiang

机构信息

Heshan District Maternal and Child Health Hospital of Yiyang City in Hunan Province, Yiyang 413002, China.

National Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, China.

出版信息

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2013 Oct;25(5):555-6.

PMID:24490384

Abstract

OBJECTIVE

To explore an effective therapy for pregnant Toxoplasma gondii infection by using acetyl spiramycin combined with azithromycin.

METHODS

ELISA and PCR were used to diagnose and evaluate the therapy efficiency to toxoplasmosis in pregnant women.

RESULTS

The serological test showed that the positive rates of specific antibodies IgM and IgG to Toxoplasma gondii in 285 pregnant women were 1.05% (3/285) and 5.97% (17/285), respectively. All the 3 cases of serum IgM positive pregnant women received the amniotic fluid PCR tests for Toxoplasma gondii DNA and 2 were positive, and they received spiramycin combined with azithromycin. After the therapy, their serum IgM antibody specific to Toxoplasma gondii and positive amniotic fluid PCR test for Toxoplasma gondii DNA turned to be negative.

CONCLUSION

Acetyl spiramycin in combination with azithromycin is effective in the treatment of pregnant toxoplasmosis.

摘要

目的

探讨乙酰螺旋霉素联合阿奇霉素治疗妊娠期弓形虫感染的有效疗法。

方法

采用酶联免疫吸附测定（ELISA）和聚合酶链反应（PCR）诊断并评估孕妇弓形虫病的治疗效果。

结果

血清学检测显示，285例孕妇中弓形虫特异性抗体IgM和IgG的阳性率分别为1.05%（3/285）和5.97%（17/285）。3例血清IgM阳性孕妇均接受了羊水弓形虫DNA的PCR检测，其中2例呈阳性，她们接受了螺旋霉素联合阿奇霉素治疗。治疗后，她们血清中弓形虫特异性IgM抗体及羊水弓形虫DNA PCR检测阳性均转为阴性。