来源于深海放线菌 Streptomyces sp. SCSIO 10355 的重排土青木香型倍半萜 Strepsesquitriol。
Strepsesquitriol, a rearranged zizaane-type sesquiterpenoid from the deep-sea-derived actinomycete Streptomyces sp. SCSIO 10355.
机构信息
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
出版信息
J Nat Prod. 2013 Dec 27;76(12):2360-3. doi: 10.1021/np400923c. Epub 2013 Dec 11.
Strepsesquitriol, a new caged sesquiterpene, was isolated from Streptomyces sp. SCSIO 10355. Its absolute structure was established as (1R,2R,4S,5S,8S,10S)-4,9,9,10-tetramethyl-2,5,10-trihydroxytricyclo[6.2.1.0(1,5)]undecane by NMR analysis and a theoretical optical rotation derived from quantum-chemical calculations. It showed moderate inhibitory activity against lipopolysaccharide-induced TNFα production in RAW264.7 macrophages.
从链霉菌 SCSIO 10355 中分离得到新的笼状倍半萜 Strepsesquitriol。通过 NMR 分析和量子化学计算得到的理论旋光值，确定其绝对构型为（1R,2R,4S,5S,8S,10S）-4,9,9,10-四甲基-2,5,10-三羟基三环[6.2.1.0(1,5)]十一烷。它对 RAW264.7 巨噬细胞中脂多糖诱导的 TNFα 产生具有中等抑制活性。
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