Hoang Le Son, Tran Manh Hung, Lee Joo-Sang, Ngo Quynh Mai Thi, Woo Mi Hee, Min Byung Sun
College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu.
Chem Pharm Bull (Tokyo). 2016;64(5):507-11. doi: 10.1248/cpb.c15-00805.
Three new sesquiterpenoids, 13-hydroxyl-atractylenolide II (1), 4-ketone-atractylenolide III (2), and eudesm-4(15)-ene-7β,11-diol (3), along with eleven known compounds (4-14), were isolated from the rhizomes of Atractylodes macrocephala. The structures and relative configurations of 1-3 were determined by analysis of the spectroscopic data, and the absolute configurations of 1 and 2 were assigned by circular dichroism technique. The anti-inflammatory activities of these isolates were evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cells; compounds 4, 7, and 8 exhibited moderate efficacy with IC50 values of 48.6±0.5, 46.4±3.2, and 32.3±2.9 µM, respectively.
从白术根茎中分离出三种新的倍半萜类化合物，13-羟基苍术内酯II（1）、4-酮基苍术内酯III（2）和桉叶-4(15)-烯-7β,11-二醇（3），以及十一种已知化合物（4-14）。通过光谱数据分析确定了1-3的结构和相对构型，并采用圆二色技术确定了1和2的绝对构型。评估了这些分离物对巨噬细胞RAW264.7中脂多糖诱导的一氧化氮产生的抗炎活性；化合物4、7和8表现出中等效力，IC50值分别为48.6±0.5、46.4±3.2和32.3±2.9μM。
