Universidad de Zaragoza, Instituto de Nanociencia de Aragón , Zaragoza , Spain.
Expert Opin Drug Deliv. 2014 Apr;11(4):547-64. doi: 10.1517/17425247.2014.884556. Epub 2014 Feb 3.
Nanostructured lyotropic liquid crystal particles (LLC NPs) have proven to be extremely useful tools for applications in drug delivery. These structured nanoparticles are formed by amphiphilic molecules and contain internal water channels, which are not in contact with external water, and where polar drugs can situate; on the other hand, apolar drugs can be loaded in the lipophilic part of the structure and the amphiphilic drugs can locate at the polar/apolar interfaces.
A revision of the most relevant results published in the field of LLC NPs has been made. The first section discusses the most common compounds used in these nanoparticles and their preparation and characterization. A summary of recent and relevant results including the composition and type of nanoparticles used, the illness treated, the administration via and some special features in each case have been summarized in a table.
LLC NPs are highly versatile drug delivery systems, which can be applied by topical, oral and intravenous treatments. Especially relevant is their use for the release of anticancer drugs, biomolecules and vaccines. Nevertheless a number of critical points need to be solved in order to attain practical applications.
纳米结构溶致液晶颗粒（LLC NPs）已被证明是药物传递应用中非常有用的工具。这些结构纳米颗粒由两亲性分子形成，包含内部水通道，这些通道与外部水不接触，极性药物可以位于其中；另一方面，非极性药物可以装载在结构的亲脂部分，而两亲性药物可以位于极性/非极性界面。
对 LLC NPs 领域中发表的最相关结果进行了综述。第一节讨论了这些纳米颗粒中最常用的化合物及其制备和表征。总结了最近和相关的结果，包括使用的纳米颗粒的组成和类型、治疗的疾病、通过的给药途径以及每种情况下的一些特殊特征，并以表格形式总结。
LLC NPs 是一种多功能的药物传递系统，可通过局部、口服和静脉治疗应用。特别相关的是它们在释放抗癌药物、生物分子和疫苗方面的应用。然而，为了实现实际应用，还需要解决一些关键问题。
