Kudriabets Iu I, Vorontsova A L, Orlovskiĭ A A, Pel'kis F P, Chekhun V F
Eksp Onkol. 1987;9(6):58-61.
The effect of interferon (IF) on the activity of multipurpose hepatic oxidases (MHO) in animals in the process of metastatic tumour development as well as interaction of IF and vinblastine (VBL) in the cell culture have been studied. IF activates MHO under conditions of their inhibition at the beginning of the tumour development and inhibits them to the normal level under activation in the postmetastatic period. Contrary to the data obtained in vivo IF does not decrease the toxicity of VBL for the tumour cells in vitro. The data obtained evidence for the modulating effect of IF on the MHO system under the tumour development.
研究了干扰素（IF）在转移性肿瘤发展过程中对动物体内多功能肝氧化酶（MHO）活性的影响，以及在细胞培养中IF与长春碱（VBL）的相互作用。在肿瘤发展初期MHO受到抑制的情况下，IF可激活MHO，而在转移后期MHO被激活时，IF又可将其抑制至正常水平。与体内获得的数据相反，IF在体外并不会降低VBL对肿瘤细胞的毒性。所获数据证明了IF在肿瘤发展过程中对MHO系统具有调节作用。
