Shmal'ko Iu P, Pridatko O E, Smelkova M I
Vopr Med Khim. 1985 May-Jun;31(3):57-60.
Functions of adrenal gland cortex, mediator system of brain and of sympathoadrenal system, including hormone formation in medullar layer of adrenal glands, were studied in mice of C57BL strain with growing metastatic Lewis carcinoma. The neurohormonal activity was distinctly inhibited under conditions of stress within the period of adaptation to the tumor development (I-14 days after the carcinoma inoculation) as well as in development of metastases (21 day of the tumor growth). Excessive stimulation of the systems studied as well as their exhaustion, might cause a distinct augmenting effect on the tumor growth and development of metastases.
在患有不断发展的转移性Lewis癌的C57BL品系小鼠中，研究了肾上腺皮质、脑中介系统和交感肾上腺系统的功能，包括肾上腺髓质层中的激素形成。在适应肿瘤发展的时期（接种癌后1-14天）以及转移发展期（肿瘤生长21天）的应激条件下，神经激素活性明显受到抑制。对所研究系统的过度刺激及其耗竭，可能会对肿瘤生长和转移发展产生明显的增强作用。
