Devesa Marta, Martínez Francisca, Coroleu Buenaventura, Rodríguez Ignacio, González Clara, Barri Pedro Nolasco
Service of Reproductive Medicine, Department of Obstetrics, Gynecology and Reproductive Medicine, Hospital Universitari Quirón-Dexeus, Gran Vía Carles III 71-75, 08028, Barcelona, Spain,
J Assist Reprod Genet. 2014 May;31(5):583-8. doi: 10.1007/s10815-014-0183-6. Epub 2014 Feb 4.
To evaluate the ovarian response to controlled ovarian hyperstimulation (COH) in cancer patients according to an age-specific nomogram for the number of retrieved oocytes.
Retrospective observational study carried out in a University affiliated fertility clinic. Forty-eight patients with cancer underwent ovarian stimulation for oocyte cryopreservation. An age - specific nomogram for the number of retrieved oocytes was built with 1536 IVF cycles due to male factor exclusively, oocyte donation and age related fertility preservation. The number of oocytes retrieved in cancer patients was compared to the expected response according to the nomogram using the Z-score.
The mean number of total retrieved oocytes in patients with cancer was 14.04 ± 8.83. After applying the Z-score to compare the number of retrieved oocytes between women with cancer and the expected response according to the age-specific nomogram, we did not observe a statistically significant difference (Z-score 0.23; 95 % CI [-0.13-0.60]).
CONCLUSION(S): According to our results, patients with cancer exhibit an ovarian response as expected by age. Despite the limitation of the sample size, the obtained results should encourage oncologists for early referral of women with cancer to fertility specialists.
根据特定年龄的取卵数列线图，评估癌症患者对控制性卵巢刺激（COH）的卵巢反应。
在一家大学附属生育诊所进行回顾性观察研究。48例癌症患者接受了卵巢刺激以进行卵母细胞冷冻保存。利用1536个仅因男性因素、卵母细胞捐赠及与年龄相关的生育力保存而进行的体外受精（IVF）周期，构建了特定年龄的取卵数列线图。使用Z分数将癌症患者的取卵数与根据列线图预期的反应进行比较。
癌症患者的总取卵数平均为14.04±8.83。在应用Z分数比较癌症女性的取卵数与根据特定年龄列线图预期的反应后，我们未观察到统计学上的显著差异（Z分数0.23；95%置信区间[-0.13 - 0.60]）。
根据我们的结果，癌症患者的卵巢反应与按年龄预期的情况相符。尽管样本量有限，但所获得的结果应促使肿瘤学家尽早将癌症女性转诊至生育专家处。
