Herbort C P, Zografos L, Zwingli M, Schoeneich M
Department of Ophthalmology, Lausanne University School of Medicine, Switzerland.
Graefes Arch Clin Exp Ophthalmol. 1988;226(1):22-6. doi: 10.1007/BF02172711.
We report four cases of corneoconjunctival keratinization that were successfully treated with topical retinoic acid ointment. In two cases keratinization was due to squamous metaplasia and in two others it was secondary to intraepithelial corneoconjunctival neoplasia. Treatment reversed severe keratinization in a case of drug-induced pseudopemphigoid and stabilized the disease in one of the two affected eyes without additional treatment. In a case of ocular cicatricial pemphigoid, retinoic acid was useful as an adjuvant therapy to immunosuppression, by reversing keratinization of the conjunctiva. In two cases of corneoconjunctival neoplasia, lesions regressed markedly. Long-term treatment was well tolerated in three patients. Our findings suggest that retinoic acid ointment is effective in treating severe squamous metaplasia in cicatrizing diseases of the conjunctiva. Our findings indicate further that retinoic acid seems to inhibit growth of corneoconjunctival neoplasias and thus might be useful complementary therapy in this situation.
我们报告了4例采用局部维甲酸软膏成功治疗的角膜结膜角化病例。其中2例角化是由于鳞状化生，另外2例继发于角膜结膜上皮内瘤变。在1例药物性类天疱疮病例中，治疗逆转了严重的角化，并且在未进行额外治疗的情况下，使2只患眼中的1只病情稳定。在1例瘢痕性类天疱疮病例中，维甲酸作为免疫抑制的辅助治疗手段，通过逆转结膜角化发挥了作用。在2例角膜结膜瘤变病例中，病变明显消退。3例患者对长期治疗耐受性良好。我们的研究结果表明，维甲酸软膏在治疗结膜瘢痕化疾病中的严重鳞状化生方面有效。我们的研究结果进一步表明，维甲酸似乎能抑制角膜结膜瘤变的生长，因此在这种情况下可能是一种有用的辅助治疗方法。
