Dafny N, Lee J R, Dougherty P M
Department of Neurobiology and Anatomy, University of Texas Medical School at Houston 77225.
J Neurosci Res. 1988;19(1):130-9. doi: 10.1002/jnr.490190118.
The present report provides evidence to support the hypothesis that peptides released during an immune response alter CNS activity and thus may provide a means for the immune system to transmit afferent signals into the brain. Specifically, it is demonstrated that recombinant interferon-alpha (rIFN-alpha), a peptide associated with the immune response to viral infection, can alter opiate withdrawal severity in a dose-dependent manner upon direct injection into brain areas essential for this phenomenon. These results are compared and contrasted with the effect of systemically injected rIFN-alpha upon opiate withdrawal. In addition, an electrophysiological investigation into the basis of the interaction of opioids and rIFN-alpha in brain structures essential for the expression of opioid activities is also presented. Finally, the effects of rIFN-alpha upon the functions of both the CNS and other systems is discussed in terms of the effects reported for other peptides associated with immune responses.
本报告提供了证据，以支持这样一种假说：免疫反应过程中释放的肽会改变中枢神经系统的活动，因此可能为免疫系统向大脑传递传入信号提供一种方式。具体而言，已证明重组干扰素-α（rIFN-α），一种与病毒感染免疫反应相关的肽，直接注射到对该现象至关重要的脑区后，能以剂量依赖的方式改变阿片类药物戒断的严重程度。将这些结果与全身注射rIFN-α对阿片类药物戒断的影响进行了比较和对比。此外，还对阿片类药物和rIFN-α在对阿片类活性表达至关重要的脑结构中的相互作用基础进行了电生理研究。最后，根据对其他与免疫反应相关肽的报道效应，讨论了rIFN-α对中枢神经系统和其他系统功能的影响。
