Dougherty P M, Dafny N
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77025.
Exp Neurol. 1987 Nov;98(2):301-16. doi: 10.1016/0014-4886(87)90244-5.
Exposure to low doses of gamma irradiation results in the modification of both the antinociceptive properties of morphine and the severity of naloxone-precipitated withdrawal in morphine-dependent rats. To better define the interactions between gamma irradiation and these opiate-mediated phenomena, dose-response studies were undertaken of the effect of irradiation on morphine-induced antinociception, and on the naloxone-precipitated withdrawal syndrome of morphine-dependent rats. In addition, electrophysiologic studies were conducted in rats after irradiation exposure and morphine treatment correlating with the behavioral studies. The observations obtained demonstrated that the antinociceptive effects of morphine as well as naloxone-precipitated withdrawal were modified in a dose-dependent manner by irradiation exposure. In addition, irradiation-induced changes in the evoked responses obtained from four different brain regions demonstrated transient alterations in both baseline and morphine-treated responses that may reflect the alterations observed in the behavioral paradigms. These results suggest that the effects of irradiation on opiate activities resulted from physiologic alterations of central endogenous opioid systems due to alterations manifested within peripheral targets.
暴露于低剂量的γ射线会导致吗啡依赖大鼠体内吗啡的抗伤害感受特性以及纳洛酮诱发的戒断症状严重程度发生改变。为了更好地界定γ射线与这些阿片介导现象之间的相互作用，我们开展了剂量反应研究，观察辐射对吗啡诱导的抗伤害感受以及吗啡依赖大鼠纳洛酮诱发的戒断综合征的影响。此外，在辐射暴露和吗啡治疗后的大鼠中进行了电生理研究，并将其与行为学研究相关联。所获得的观察结果表明，辐射暴露以剂量依赖的方式改变了吗啡的抗伤害感受作用以及纳洛酮诱发的戒断反应。此外，从四个不同脑区获得的诱发反应中，辐射诱导的变化显示基线反应和吗啡处理后的反应均出现短暂改变，这可能反映了行为模式中观察到的变化。这些结果表明，辐射对阿片活性的影响是由于外周靶点内表现出的改变导致中枢内源性阿片系统发生生理改变所致。
