肿瘤坏死因子-α（TNF-α）基因启动子G-308A多态性在2型糖尿病患者血糖控制中的作用。
The role of TNF-α G-308A promoter polymorphism in glycemic control in Type 2 diabetes patients.
作者信息
Al-Azzam S I, Khabour O F, Alzoubi K H, Ghanma M W, Alhasan A Y
机构信息
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, 22110, Jordan,
出版信息
J Endocrinol Invest. 2014 Feb;37(2):113-8. doi: 10.1007/s40618-013-0002-4. Epub 2014 Jan 9.
BACKGROUND
TNF-α polymorphisms were shown to be associated with insulin resistance and diabetes development and complications.
AIM
To investigate the association between glycemic control in Type 2 diabetes patients and TNF-α G-308A single nucleotide polymorphism (SNP).
METHODS
This was a cross-sectional observational study, where diabetes patients from both genders (170 male and 185 female) were enrolled in the study. Patients were divided into two groups: good glycemic control (n = 158) and poor glycemic control (n = 197). Genotyping of TNF-α G-308A SNP was carried out using restriction fragment length polymorphisms-polymerase chain reaction.
RESULTS
The results showed that TNF-α G-308A SNP is strongly associated with glycemic control in type 2 diabetes patients. Patients with the AA and AG genotypes had better glycemic control than those with GG genotype (P < 0.01). Other parameters that impacted glycemic control include duration of the disease (P < 0.01) and response to insulin therapy (P < 0.01). However, no contribution for gender or statins use to glycemic control was observed (P > 0.05).
CONCLUSION
TNF-α G-308A SNP might modulate glycemic control among type 2 diabetes patients.
背景
肿瘤坏死因子-α（TNF-α）基因多态性与胰岛素抵抗、糖尿病的发生及并发症相关。
目的
探讨2型糖尿病患者血糖控制与TNF-α基因G-308A单核苷酸多态性（SNP）之间的关联。
方法
这是一项横断面观察性研究，纳入了男女糖尿病患者（男性170例，女性185例）。患者被分为两组：血糖控制良好组（n = 158）和血糖控制不佳组（n = 197）。采用限制性片段长度多态性-聚合酶链反应对TNF-α基因G-308A SNP进行基因分型。
结果
结果显示，TNF-α基因G-308A SNP与2型糖尿病患者的血糖控制密切相关。AA和AG基因型患者的血糖控制优于GG基因型患者（P < 0.01）。影响血糖控制的其他因素包括病程（P < 0.01）和胰岛素治疗反应（P < 0.01）。然而，未观察到性别或他汀类药物使用对血糖控制有影响（P > 0.05）。
结论
TNF-α基因G-308A SNP可能调节2型糖尿病患者的血糖控制。
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