Nattino Giovanni, Finazzi Stefano, Bertolini Guido
GiViTI Coordinating Center, Laboratory of Clinical Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Villa Camozzi, Ranica (BG), Italy.
Stat Med. 2014 Jun 30;33(14):2390-407. doi: 10.1002/sim.6100. Epub 2014 Feb 4.
Calibration is one of the main properties that must be accomplished by any predictive model. Overcoming the limitations of many approaches developed so far, a study has recently proposed the calibration belt as a graphical tool to identify ranges of probability where a model based on dichotomous outcomes miscalibrates. In this new approach, the relation between the logits of the probability predicted by a model and of the event rates observed in a sample is represented by a polynomial function, whose coefficients are fitted and its degree is fixed by a series of likelihood-ratio tests. We propose here a test associated with the calibration belt and show how the algorithm to select the polynomial degree affects the distribution of the test statistic. We calculate its exact distribution and confirm its validity via a numerical simulation. Starting from this distribution, we finally reappraise the procedure to construct the calibration belt and illustrate an application in the medical context.
校准是任何预测模型都必须具备的主要特性之一。为克服目前已开发的许多方法的局限性,最近一项研究提出将校准带作为一种图形工具,以识别基于二分结果的模型校准错误的概率范围。在这种新方法中,模型预测概率的对数与样本中观察到的事件发生率之间的关系由一个多项式函数表示,该函数的系数通过拟合得到,其次数由一系列似然比检验确定。我们在此提出一种与校准带相关的检验,并展示选择多项式次数的算法如何影响检验统计量的分布。我们计算其精确分布,并通过数值模拟确认其有效性。从这个分布出发,我们最终重新评估构建校准带的过程,并举例说明其在医学领域的应用。