Sułowska Z, Brzezińska-Błaszczyk E, Czuwaj M
Department of Biogenic Amines, Polish Academy of Sciences, Lódź.
Arch Immunol Ther Exp (Warsz). 1987;35(4):541-6.
The action of supernatants from cultivated in vitro guinea pig spleen cells on the mast cells of guinea pigs, rats and hamsters was studied. It was found that supernatants from guinea pig spleen cell cultures are potent to release histamine from mast cells of the examined populations in a dose-dependent fashion. Histamine release from heterologous mast cells (especially from rat pleural mast cells) was significantly higher than that from homologous mesenteric mast cells. It was also demonstrated (on rat mast cells) that guinea pig spleen cell supernatants possessed not only histamine but 5-hydroxytryptamine releasing activity as well. Rat pleural mast cells were more sensitive and released more serotonin after challenge with spleen cell supernatants than peritoneal cells.
研究了体外培养的豚鼠脾细胞上清液对豚鼠、大鼠和仓鼠肥大细胞的作用。发现豚鼠脾细胞培养上清液能够以剂量依赖的方式从所检测群体的肥大细胞中释放组胺。异源肥大细胞（尤其是大鼠胸膜肥大细胞）释放的组胺明显高于同源肠系膜肥大细胞。还证明（在大鼠肥大细胞上）豚鼠脾细胞上清液不仅具有组胺释放活性，还具有5-羟色胺释放活性。与腹膜细胞相比，大鼠胸膜肥大细胞在用脾细胞上清液刺激后更敏感，释放的5-羟色胺更多。
