Alam R, Wyczółkowska J, Sułowska Z
Agents Actions. 1986 Apr;18(1-2):163-6. doi: 10.1007/BF01988011.
There has been the lack of small animal models for the studies of histamine releasing factor (HRF). We have found that HRF produced in vitro by lymphocytes of asthmatic patients can act independently from the animal species and induces histamine secretion from mouse peritoneal mast cells. We also found, that spleen cells derived from normal as well as from sensitized mice and guinea-pigs are able to generate HRF in vitro, when cultured in suitable conditions. HRF of mouse and guinea-pig origin released histamine from homologous mast cells in vitro and its activity was enhanced when spleen cell cultures were stimulated with specific antigens or non-specific mitogen.
一直缺乏用于组胺释放因子（HRF）研究的小动物模型。我们发现，哮喘患者淋巴细胞在体外产生的HRF可独立于动物物种发挥作用，并诱导小鼠腹腔肥大细胞分泌组胺。我们还发现，来自正常小鼠以及致敏小鼠和豚鼠的脾细胞，在合适条件下培养时能够在体外产生HRF。源自小鼠和豚鼠的HRF在体外可从同源肥大细胞释放组胺，当脾细胞培养物受到特异性抗原或非特异性有丝分裂原刺激时，其活性会增强。
