Reibel J, Wallenius K, Dabelsteen E
Department of Oral Pathology, Royal Dental College, Copenhagen, Denmark.
APMIS. 1988 Feb;96(2):161-7. doi: 10.1111/j.1699-0463.1988.tb05284.x.
During 4-nitroquinoline-1-oxide-induced carcinogenesis in the rat palate, animals were sacrificed at various intervals and stained for blood group antigens B and H (Type 2 chain) by an immunofluorescent method. In rats without signs of epithelial dysplasia, the staining pattern was identical with that in the normal control rats. In rats with definite or questionable (borderline cases) dysplasias, marked changes in blood group antigen staining pattern were seen. Thus, changes in cell-surface carbohydrates during malignant development in the rat palate seem to follow closely the histomorphological changes. As there is good evidence that carcinomas would eventually develop in all rats if they were not sacrificed, it seems that the blood group antigen staining pattern does not predict malignant development in the absence of histological suspicion.
在4-硝基喹啉-1-氧化物诱发大鼠腭部癌变的过程中，在不同时间点处死动物，并采用免疫荧光法对血型抗原B和H（2型链）进行染色。在没有上皮发育异常迹象的大鼠中，染色模式与正常对照大鼠相同。在有明确或可疑（临界病例）发育异常的大鼠中，观察到血型抗原染色模式有明显变化。因此，大鼠腭部恶性发展过程中细胞表面碳水化合物的变化似乎与组织形态学变化密切相关。由于有充分证据表明，如果不处死所有大鼠，最终都会发生癌变，所以在没有组织学怀疑的情况下，血型抗原染色模式似乎无法预测恶性发展。
