Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
J Nat Prod. 2014 Feb 28;77(2):270-5. doi: 10.1021/np400833x. Epub 2014 Feb 5.
Five new fungal hybrid polyketides, cladosins A-D (1-4), that contain a novel linear 6(3)-enamino-8,10-dihydroxy-tetraketide (1 and 2) or 6-enamino-7(8)-en-10-ol (3 and 4) moiety, as well as the biogenetically related cladosin E (5), were isolated from the deep-sea-derived fungus Cladosporium sphaerospermum 2005-01-E3. Their structures (1-5) were elucidated through a combination of spectroscopic data, chemical conversion, and both Mosher's and Marfey's methods for stereochemical assignment. A plausible biogenetic pathway to 1-5 is proposed. Cladosin C (3) possesses mild anti-influenza A H1N1 virus activity.
五种新型真菌杂合聚酮化合物，cladosins A-D（1-4），含有一个新颖的线性 6(3)-enamino-8,10-二羟基四酮（1 和 2）或 6-enamino-7(8)-en-10-ol（3 和 4）部分，以及生物相关的 cladosin E（5），从深海来源的真菌 Cladosporium sphaerospermum 2005-01-E3 中分离得到。通过光谱数据、化学转化以及莫舍尔法和马费伊法的立体化学归属，确定了它们的结构（1-5）。提出了一个可能的生物合成途径。Cladosin C（3）具有温和的抗甲型流感 H1N1 病毒活性。
