来自植物内生真菌枝孢菌属IFB3lp-2的聚酮化合物。

Polyketides from the plant endophytic fungus Cladosporium sp. IFB3lp-2.

作者信息

Guo Zhi-Kai, Wei Wei, Jiao Rui-Hua, Yan Tong, Zang Le-Yun, Jiang Rong, Tan Ren-Xiang, Ge Hui-Ming

机构信息

a Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing , 210093 , China.

出版信息

J Asian Nat Prod Res. 2013 Sep;15(9):928-33. doi: 10.1080/10286020.2013.817389. Epub 2013 Aug 5.

DOI:10.1080/10286020.2013.817389

PMID:23909809

Abstract

Chemical study of the ethyl acetate extract of the plant endophytic fungus Cladosporium sp. (strain no. IFB3lp-2) yielded three new polyketides (1-3), together with nine known compounds. All of the structures were elucidated on the basis of spectroscopic methods. The isolated compounds were screened for their cytotoxic, antiviral, and acetyl cholinesterase inhibitory activities. Regretfully, no compounds showed any significant activity in these assays.

摘要

对植物内生真菌枝孢菌属（菌株编号IFB3lp - 2）的乙酸乙酯提取物进行化学研究，得到了三种新的聚酮化合物（1 - 3）以及九种已知化合物。所有结构均通过光谱方法得以阐明。对分离出的化合物进行了细胞毒性、抗病毒和乙酰胆碱酯酶抑制活性的筛选。遗憾的是，在这些测定中没有化合物显示出任何显著活性。