Department of Chemistry & Chemical Biology, University of New Mexico , Albuquerque, New Mexico 87131, United States.
Org Lett. 2014 Feb 21;16(4):1264-7. doi: 10.1021/ol500310u. Epub 2014 Feb 5.
An efficient Cu(I)-catalyzed Suzuki-Miyaura reaction was developed for the coupling of aryl- and heteroarylboronate esters with aryl and heteroaryl iodides at low catalyst loadings (2 mol %). The reaction proceeds under ligand-free conditions for aryl-heteroaryl and heteroaryl-heteroaryl couplings. We also conducted the first detailed mechanistic studies by synthesizing [(PN-2)CuI]2, [(PN-2)CuF]2, and (PN-2)CuPh (PN-2 = o-(di-tert-butylphosphino)-N,N-dimethylaniline) and demonstrated that [(PN-2)CuF]2 is the species that undergoes transmetalation with arylboronate esters.
发展了一种高效的 Cu(I)催化的 Suzuki-Miyaura 反应，用于在低催化剂负载量（2 mol%）下实现芳基硼酸酯与芳基和杂芳基碘化物的偶联。该反应在无配体条件下进行，适用于芳基-杂芳基和杂芳基-杂芳基偶联。我们还通过合成 [(PN-2)CuI]2、[(PN-2)CuF]2 和 (PN-2)CuPh（PN-2 = o-(二-叔丁基膦基)-N,N-二甲基苯胺）进行了首次详细的机理研究，并证明 [(PN-2)CuF]2 是与芳基硼酸酯进行转金属化的物种。
