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2004年英国酒精依赖治疗率上升的潜在影响。

The potential impact of increased treatment rates for alcohol dependence in the United Kingdom in 2004.

作者信息

Shield Kevin D, Rehm Jürgen, Rehm Maximilien X, Gmel Gerrit, Drummond Colin

机构信息

Centre for Addiction and Mental Health (CAMH), 33 Russell Street, Toronto, ON M5S 2S1, Canada.

出版信息

BMC Health Serv Res. 2014 Feb 5;14:53. doi: 10.1186/1472-6963-14-53.

Abstract

BACKGROUND

Alcohol consumption has been linked to a considerable burden of disease in the United Kingdom (UK), with most of this burden due to heavy drinking and Alcohol Dependence (AD). However, AD is undertreated in the UK, with only 8% of those individuals with AD being treated in England and only 6% of those individuals with AD being treated in Scotland. Thus, the objective of this paper is to quantify the deaths that would have been avoided in the UK in 2004 if the treatment rate for AD had been increased.

METHODS

Data on the prevalence of AD, alcohol consumption, and mortality were obtained from the Adult Psychiatric Morbidity Survey, the Global Information System on Alcohol and Health, and the 2004 Global Burden of Disease study respectively. Data on the effectiveness of pharmacological treatment and Motivational Interviewing/Cognitive Behavioural Therapy were obtained from Cochrane reviews and meta-analyses. Simulations were used to model the number of deaths under different treatment scenarios. Sensitivity analyses were performed to model the effects of Brief Interventions and to examine the effect of using AD prevalence data obtained from the National Institute for Health and Clinical Excellence.

RESULTS

In the UK, 320 female and 1,385 male deaths would have been avoided if treatment coverage of pharmacological treatment had been increased to 20%. This decrease in the number of deaths represents 7.9% of all alcohol-attributable deaths (7.0% of all alcohol-attributable deaths for women and 8.1% of all alcohol-attributable deaths for men). If we used lower AD prevalence rates obtained from the National Institute for Health and Clinical Excellence, then treatment coverage of pharmacological treatment in hospitals for 20% of the population with AD would have resulted in the avoidance of 529 deaths in 2004 (99 deaths avoided for women and 430 deaths avoided for men).

CONCLUSIONS

Increasing AD treatment in the UK would have led to a large number of deaths being avoided in 2004. Increased AD treatment rates not only impact mortality but also impact upon the large burden of disability and morbidity attributable to AD, as well as the associated social and economic burdens.

摘要

背景

在英国,饮酒与相当大的疾病负担相关,其中大部分负担归因于重度饮酒和酒精依赖(AD)。然而,在英国,酒精依赖的治疗不足,在英格兰只有8%的酒精依赖患者接受治疗,在苏格兰只有6%的酒精依赖患者接受治疗。因此,本文的目的是量化如果2004年酒精依赖的治疗率提高,英国本可避免的死亡人数。

方法

酒精依赖的患病率、饮酒量和死亡率数据分别来自成人精神病患病率调查、全球酒精与健康信息系统以及2004年全球疾病负担研究。药物治疗和动机访谈/认知行为疗法的有效性数据来自Cochrane综述和荟萃分析。使用模拟模型来模拟不同治疗方案下的死亡人数。进行敏感性分析以模拟简短干预的效果,并检验使用从英国国家卫生与临床优化研究所获得的酒精依赖患病率数据的影响。

结果

在英国,如果药物治疗的覆盖率提高到20%,将可避免320名女性和1385名男性死亡。死亡人数的减少占所有酒精相关死亡人数的7.9%(女性所有酒精相关死亡人数的7.0%,男性所有酒精相关死亡人数的8.1%)。如果我们使用从英国国家卫生与临床优化研究所获得的较低的酒精依赖患病率,那么医院对20%的酒精依赖人群进行药物治疗的覆盖率将导致2004年避免529例死亡(女性避免99例死亡,男性避免430例死亡)。

结论

在英国增加酒精依赖的治疗将在2004年避免大量死亡。提高酒精依赖的治疗率不仅会影响死亡率,还会影响因酒精依赖导致的大量残疾和发病率负担,以及相关的社会和经济负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0871/3923387/6f87306ed979/1472-6963-14-53-1.jpg

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