Kajaria Divya, Tripathi Jyoti Shankar, Tiwari Shri Kant, Pandey Bajrangi Lal
Assistant Professor, Department of Kayachikitsa, C.B.P.A.C.S, New Delhi, India.
Associate Professor, Department of Kayachikitsa, IMS, BHU, Varanasi, Uttar Pradesh, India.
Ayu. 2013 Jul;34(3):322-6. doi: 10.4103/0974-8520.123136.
Immunomodulators are substances that helps to regulate the immune system. The basic mechanisms by which the herbs defend the body against infection have two probable ways- one by destroying pathogens and other by enhancing the body immunity. Shirishadi compound is a polyherbal drug used in Ayurvedic system of medicine for the management of allergic disorders such as allergic rhinitis, allergic asthma etc., The present study was carried out to evaluate the immunomodulatory activity of ethanolic extract of polyherbal compound "Shirishadi" on Swiss albino mice. Cyclophosphamide (CP) induced immunosuppression model was used to assess the activity of drug. CP was given in the dose of 30 mg/kg body weight through i.p route. 500 mg/kg body weight of Shirishadi polyherbal drug was given through oral route. The extent of protection against immunosuppression caused by CP was evaluated after 14 days of drug administration, by estimating hematological parameters and neutrophil adhesion test. Ethanolic extracts of Shirishadi compound showed pronounced immunoprotective activity by increasing the depleted levels of total WBC count and RBC, % Hb, and % neutrophils adhesion. The extract was found to be an effective immunomodulatory agent.
免疫调节剂是有助于调节免疫系统的物质。草药保护身体免受感染的基本机制可能有两种方式——一种是通过破坏病原体，另一种是通过增强身体免疫力。Shirishadi复方是一种用于阿育吠陀医学体系治疗过敏性疾病（如过敏性鼻炎、过敏性哮喘等）的多草药药物。本研究旨在评估多草药复方“Shirishadi”乙醇提取物对瑞士白化小鼠的免疫调节活性。采用环磷酰胺（CP）诱导的免疫抑制模型来评估药物活性。通过腹腔注射途径给予CP，剂量为30mg/kg体重。通过口服途径给予500mg/kg体重的Shirishadi多草药药物。给药14天后，通过估计血液学参数和中性粒细胞黏附试验，评估对CP引起的免疫抑制的保护程度。Shirishadi复方的乙醇提取物通过增加白细胞总数、红细胞、血红蛋白百分比和中性粒细胞黏附百分比的降低水平，表现出显著的免疫保护活性。该提取物被发现是一种有效的免疫调节药物。
