Division of Phytochemistry and Drug Design, Department of Biosciences, Rajagiri College of Social Sciences, Cochin, Kerala, 683 104, India.
Department of Chemistry, Government College of Engineering, Sengipatti, Thanjavur, Tamil Nadu, 613 402, India.
Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):2747-2775. doi: 10.1007/s00210-023-02822-w. Epub 2023 Nov 21.
Guilandina bonduc L. is popularly known as a fever nut that grows widely in evergreen forests and moist deciduous forests with a pantropical distribution. The plant is highly therapeutic in various systems of medicine, including Ayurveda, Siddha, and homeopathy. The purpose of this review is to analyze the published data on G. bonduc, including traditional uses, taxonomic position, botanical description, phytochemistry, pharmacological properties, and toxicological assessment of its various parts. Phytochemical and pharmacological studies were the main focus of this review. The previously published research on G. bonduc was tracked from scientific databases such as Online Library, Google, Taylor and Francis, PubMed, Research Gate, Scopus, Springer, Wiley, Web of Sciences. Numerous phytochemical, pharmaceutical, and pharmacological studies have been carried out on the various parts of G. bonduc. To date, more than 97 phytochemicals have been isolated from the leaves, roots, stems, stem bark, flowers, twigs, and seeds of this plant. The phytochemicals isolated from the plants are flavonoids, homoisoflavonoids, terpenoids, diterpenoids, steroids, fatty acids, alkanes, acids, phenols, ketones, esters, amides, azides, silanes, and ether groups. This plant has been extensively studied in in vitro and in vivo pharmacological experiments, where it showed analgesic, anti-inflammatory, antioxidant, antiviral, antidiabetic, abortive, anticataleptic, immunomodulatory, and antiestrogenic effects. This comprehensive review revealed that phytochemicals isolated from various parts of G. bonduc have significant therapeutic efficacy, with promising anticancer, antidiabetic, hepatoprotective, antioxidant, and antimicrobial activities. This review provides a good source of information for the development of a drug using modern scientific tools, in view of its underexplored traditional uses. Further studies on preclinical and clinical trials and toxicological studies on the bioactive molecules of G. bonduc to validate its traditional uses are warranted.
翅榴是一种广泛分布于热带雨林和湿润落叶林中的常绿植物，俗称退热果。该植物在包括阿育吠陀、悉达和顺势疗法在内的各种医学体系中具有高度的治疗作用。本综述的目的是分析已发表的关于翅榴的文献资料，包括传统用途、分类地位、植物描述、植物化学、药理学特性以及其各部分的毒理学评估。本综述主要关注植物化学和药理学研究。之前对翅榴的研究是从 Online Library、Google、Taylor and Francis、PubMed、Research Gate、Scopus、Springer、Wiley、Web of Sciences 等科学数据库中追踪到的。人们对翅榴的各个部分进行了大量的植物化学、药物和药理学研究。迄今为止，已从该植物的叶、根、茎、茎皮、花、嫩枝和种子中分离出 97 多种植物化学物质。从植物中分离出的植物化学物质包括类黄酮、异黄酮、萜类化合物、二萜类化合物、甾体、脂肪酸、烷烃、酸、酚类、酮类、酯类、酰胺类、叠氮化物、硅烷和醚类。该植物已在体外和体内药理学实验中进行了广泛研究，其具有镇痛、抗炎、抗氧化、抗病毒、抗糖尿病、堕胎、抗惊厥、免疫调节和抗雌激素作用。这项全面的综述表明，从翅榴各个部分分离出的植物化学物质具有显著的治疗功效，具有有前途的抗癌、抗糖尿病、保肝、抗氧化和抗菌活性。鉴于其传统用途尚未得到充分开发，本综述为利用现代科学工具开发药物提供了良好的信息来源。需要进一步研究翅榴生物活性分子的临床前和临床试验以及毒理学研究，以验证其传统用途。
