School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Immunopharmacol Immunotoxicol. 2010 Jun;32(2):272-6. doi: 10.3109/08923970903305481.
The major groups of phytonutrients found in plants include polyphenols, flavonoids, terpenes, amines, etc., all of which are observed to have potential anti-allergic activity. In this study, we evaluated the anti-allergic activity of the standardized extract of Albizia lebbeck with respect to the catechin, a polyphenolic phytomarker.
The percentage of catechin in the ethanolic extract was found to be 14.72 mg/g. We administered Albizia lebbeck (50-300 mg/kg) and 50 mg/kg of catechin to mice to evaluate the mast cell stabilization and estimation of histamine elevation in the plasma.
Results support the conclusion that Albizia lebbeck at different concentrations has got potent mast cell stabilizing property and the IC(50) value of Albizia lebbeck was found to be 85 microg/ml. This inhibitory potential of catechin from Albizia lebbeck is perhaps due to modulation of two important effector's functions, histamine release and cytokine expression of antigen -IgE activated mast cells.
植物中的植物营养素主要包括多酚、类黄酮、萜类、胺等，所有这些都被观察到具有潜在的抗过敏活性。在这项研究中，我们评估了勒比紫胶标准化提取物中儿茶素（一种多酚植物标志物）的抗过敏活性。
发现该提取物中儿茶素的含量为 14.72mg/g。我们给小鼠施用勒比紫胶（50-300mg/kg）和 50mg/kg 的儿茶素，以评估肥大细胞稳定和血浆中组胺升高的情况。
结果支持以下结论：不同浓度的勒比紫胶具有很强的肥大细胞稳定作用，并且发现勒比紫胶的 IC50 值为 85μg/ml。这种来自勒比紫胶的儿茶素的抑制作用可能是由于调节了两个重要的效应器的功能，即抗原-IgE 激活的肥大细胞中组胺的释放和细胞因子的表达。
