区域性特定地下水砷水平与神经心理学功能：一项横断面研究。
Regional specific groundwater arsenic levels and neuropsychological functioning: a cross-sectional study.
机构信息
a Department of Psychology , University of North Texas , Fort Worth , TX , USA.
出版信息
Int J Environ Health Res. 2014;24(6):546-57. doi: 10.1080/09603123.2014.883591. Epub 2014 Feb 7.
BACKGROUND
The purpose of the study was to examine the link between geographic information system (GIS)-estimated regional specific groundwater levels and neuropsychological functioning in a sample of individuals with and without cognitive impairment.
METHODS
This cross-sectional study design analyzed data from 1390 participants (733 Alzheimer's disease, 127 Mild Cognitive Impairment, and 530 with normal cognition) enrolled in the Texas Alzheimer's Research and Care Consortium. GISs analyses were used to estimate regional specific groundwater arsenic concentrations using the Environmental Systems Research Institute and arsenic concentrations from the Texas Water Development Board.
RESULTS
In the full cohort, regional specific arsenic concentrations were positively associated with language abilities (p = 0.008), but associated with poorer verbal memory, immediate (p = 0.008), and delayed (p < 0.001), as well as poorer visual memory, immediate (p = 0.02), and delayed (p < 0.001). The findings varied by diagnostic category with arsenic being related with cognition most prominently among mild cognitive impairment cases.
CONCLUSIONS
Overall, estimated regional specific groundwater arsenic levels were negatively associated with neuropsychological performance.
背景
本研究旨在探讨地理信息系统（GIS）估计的区域特定地下水位与认知障碍患者和认知正常个体神经心理学功能之间的关系。
方法
本横断面研究设计分析了德克萨斯州阿尔茨海默病研究与护理联合会招募的 1390 名参与者（733 名阿尔茨海默病患者、127 名轻度认知障碍患者和 530 名认知正常患者）的数据。使用环境系统研究所（Environmental Systems Research Institute）和德克萨斯州水发展委员会（Texas Water Development Board）的砷浓度对 GIS 进行分析，以估计区域特定的地下水砷浓度。
结果
在全队列中，区域特定的砷浓度与语言能力呈正相关（p=0.008），但与较差的言语记忆、即刻（p=0.008）和延迟（p<0.001）以及较差的视觉记忆、即刻（p=0.02）和延迟（p<0.001）相关。研究结果因诊断类别而异，砷与认知障碍的关系在轻度认知障碍患者中最为显著。
结论
总体而言，估计的区域特定地下砷水平与神经心理学表现呈负相关。
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