• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[与非肥胖2型糖尿病患者相比，肥胖2型糖尿病患者的脂质过氧化及抗氧化防御系统反应]

[Lipid peroxidation and the response of the antioxidant defense system in the obese type 2 diabetic compared with the non-obese type 2 diabetic].

作者信息

Gaxiola-Robles Ramón, Bitzer-Quintero Oscar Kurt, Méndez-Rodríguez Lía Celina, Labrada-Martagón Vanessa, García-González Adolfo, Ramírez-Jirano Luis Javier, Veléz-Alavez Marcela, Zenteno-Savín Tania

机构信息

Centro de Investigaciones Biológicas del Noroeste (CIBNOR). Planeación Ambiental y Conservación. La Paz. Baja California Sur. México. Hospital General de Zona N.º 1. Instituto Mexicano del Seguro Social. La Paz. Baja California Sur. México..

Centro de Investigación Biomédica de Occidente (CIBO). Instituto Mexicano del Seguro Social. Guadalajara. Jalisco. México..

出版信息

Nutr Hosp. 2013 Nov 1;28(6):1905-11.

PMID:24506367
Abstract

INTRODUCTION

Diabetes is associated with increased lipid peroxidation, quantified as the levels of thiobarbituric acid reactive substances (TBARS). In parallel, the antioxidant defense system (ADS) reacts to diminish the oxidative damage.

OBJECTIVE

To determine the levels of lipid peroxidation and the activity of antioxidant enzymes in obese type 2 diabetic (DM2) individuals compared to non-obese DM2 individuals.

METHODS

Lipid peroxidation was quantified by measuring TBARS and the ADS response by measuring the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx).

RESULTS

Two groups of 30 subjects were studied. The obese DM2 group had a mean body mass index (BMI) 38.6 ± 3.5 kg m(-2) compared to the control group 24.7 ± 3.6 kg m(-2) (p<0.01). TBARS levels in the study group were higher compared to the control group (p <0.01). Multiple linear regression analysis suggested that activities of SOD and CAT adjusted to lipid peroxidation (TBARS) in the obese DM2 individuals.

CONCLUSION

TBARS levels suggest greater oxidative damage in obese DM2 subjects with a diminished response of ADS.

摘要

引言

糖尿病与脂质过氧化增加有关，脂质过氧化以硫代巴比妥酸反应性物质（TBARS）水平来量化。同时，抗氧化防御系统（ADS）会做出反应以减少氧化损伤。

目的

比较肥胖的2型糖尿病（DM2）患者与非肥胖DM2患者的脂质过氧化水平和抗氧化酶活性。

方法

通过测量TBARS来量化脂质过氧化，并通过测量超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）的活性来评估ADS反应。

结果

对两组各30名受试者进行了研究。肥胖DM2组的平均体重指数（BMI）为38.6±3.5kg/m²，而对照组为24.7±3.6kg/m²（p<0.01）。研究组的TBARS水平高于对照组（p<0.01）。多元线性回归分析表明，肥胖DM2个体中SOD和CAT的活性与脂质过氧化（TBARS）相关。

结论

TBARS水平表明肥胖DM2受试者存在更大的氧化损伤，且ADS反应减弱。

相似文献

1
[Lipid peroxidation and the response of the antioxidant defense system in the obese type 2 diabetic compared with the non-obese type 2 diabetic].[与非肥胖2型糖尿病患者相比，肥胖2型糖尿病患者的脂质过氧化及抗氧化防御系统反应]
Nutr Hosp. 2013 Nov 1;28(6):1905-11.
2
Status of antioxidant and lipid peroxidation in type 2 diabetic human subjects diagnosed with and without metabolic syndrome by using NCEP-ATPIII, IDF and WHO criteria.根据美国国家胆固醇教育计划成人治疗组第三次报告（NCEP-ATPIII）、国际糖尿病联盟（IDF）和世界卫生组织（WHO）标准诊断的2型糖尿病患者中，有或无代谢综合征者的抗氧化状态和脂质过氧化情况。
Obes Res Clin Pract. 2015 Mar-Apr;9(2):158-67. doi: 10.1016/j.orcp.2014.03.004. Epub 2014 May 1.
3
Modulatory effect of vanillic acid on antioxidant status in high fat diet-induced changes in diabetic hypertensive rats.香草酸对高脂饮食诱导的糖尿病高血压大鼠抗氧化状态变化的调节作用。
Biomed Pharmacother. 2017 Mar;87:640-652. doi: 10.1016/j.biopha.2016.12.134. Epub 2017 Jan 11.
4
Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus.2型糖尿病患者的血浆脂质过氧化产物及抗氧化酶活性
Acta Diabetol. 2002 Sep;39(3):117-22. doi: 10.1007/s005920200029.
5
Mechanism for obesity-induced increase in myocardial lipid peroxidation.
Int J Obes Relat Metab Disord. 2001 Mar;25(3):378-88. doi: 10.1038/sj.ijo.0801536.
6
Changes in antioxidant enzymes and lipid peroxidation in extensor digitorum longus muscles of streptozotocin-diabetic rats may contribute to muscle atrophy.链脲佐菌素诱导的糖尿病大鼠趾长伸肌中抗氧化酶和脂质过氧化的变化可能导致肌肉萎缩。
Acta Physiol Hung. 2014 Dec;101(4):421-8. doi: 10.1556/APhysiol.101.2014.007.
7
Obesity is associated with increased myocardial oxidative stress.肥胖与心肌氧化应激增加有关。
Int J Obes Relat Metab Disord. 1999 Jan;23(1):67-74. doi: 10.1038/sj.ijo.0800761.
8
Beneficial effect of succinic acid monoethyl ester on erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-nicotinamide induced type 2 diabetes.琥珀酸单乙酯对链脲佐菌素-烟酰胺诱导的2型糖尿病患者红细胞膜结合酶及抗氧化状态的有益作用
Chem Biol Interact. 2007 Aug 15;169(1):15-24. doi: 10.1016/j.cbi.2007.04.010. Epub 2007 May 4.
9
Effect of pentylenetetrazol-induced epileptic seizure on the antioxidant enzyme activities, glutathione and lipid peroxidation levels in rat erythrocytes and liver tissues.戊四氮诱导的癫痫发作对大鼠红细胞和肝脏组织中抗氧化酶活性、谷胱甘肽及脂质过氧化水平的影响
Clin Biochem. 2005 Nov;38(11):1009-14. doi: 10.1016/j.clinbiochem.2005.07.012. Epub 2005 Aug 24.
10
Lipid peroxidation and antioxidant enzyme activities in erythrocytes of type 2 diabetic patients.2型糖尿病患者红细胞中的脂质过氧化和抗氧化酶活性
J Med Assoc Thai. 2010 Jun;93(6):682-93.

引用本文的文献

1
Pharmacological and Chemical Analysis of L. Using an In Vitro Antiadipogenic Model.使用体外抗脂肪生成模型对L进行药理和化学分析。
Plants (Basel). 2023 Nov 8;12(22):3799. doi: 10.3390/plants12223799.
2
Soluble ST2 as a New Oxidative Stress and Inflammation Marker in Metabolic Syndrome.可溶性 ST2 作为代谢综合征中新的氧化应激和炎症标志物。
Int J Environ Res Public Health. 2023 Jan 31;20(3):2579. doi: 10.3390/ijerph20032579.
3
Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet-Induced Type 2 Diabetic Mice.
有氧运动训练可改善饮食诱导的2型糖尿病小鼠的微血管功能和氧化应激参数。
Diabetes Metab Syndr Obes. 2022 Sep 28;15:2991-3005. doi: 10.2147/DMSO.S365496. eCollection 2022.