EA 4267 (FDE/UFC), Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, 7, Bd. Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Phytochemistry. 2014 Apr;100:150-5. doi: 10.1016/j.phytochem.2013.12.005. Epub 2014 Feb 4.
Four triterpenoid saponins (1-4) were isolated from Polycarpaea corymbosa Lamk. var. eriantha Hochst along with the known apoanagallosaponin IV (5). Their structures were elucidated by spectroscopic data analysis. Among the compounds 1, 3-5 which were evaluated for their cytotoxicity against three tumor cell lines (SW480, DU145 and EMT6), compound 1 exhibited cytotoxicity with IC50 values ranging from 4.61 to 22.61 μM, which was greater than that of etoposide. Compound 2 was tested only against SW480 and a cardiomyoblast cell line (H9c2), and was inactive.
从密花八角莲 Polycarpaea corymbosa Lamk. var. eriantha Hochst 中分离得到了四种三萜皂苷（1-4），并结合已知的表告依春苷 IV（5）。通过光谱数据分析阐明了它们的结构。在所评估的化合物 1、3-5 中，它们对三种肿瘤细胞系（SW480、DU145 和 EMT6）的细胞毒性，化合物 1 表现出的细胞毒性，IC50 值范围为 4.61 至 22.61 μM，大于依托泊苷。化合物 2 仅针对 SW480 和心肌细胞系（H9c2）进行了测试，没有活性。
