Tian Ye, Tang Hai-Feng, Qiu Feng, Wang Xiao-Juan, Chen Xiao-Li, Wen Ai-Dong
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, PR China.
Planta Med. 2009 Jan;75(1):70-5. doi: 10.1055/s-0028-1088369. Epub 2008 Nov 27.
Three new triterpenoid saponins 3, 4 and 5, together with two known saponins, ardisiacrispin B (1) and ardisiacrispin A (2), were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were elucidated by extensive spectral analysis and chemical evidence. Compound 3 is a hexaglycoside with a 13,28-epoxyoleanane type aglycone, while both 4 and 5 are triterpenoid tetraglycosides related to the olean-12-ene skeleton. Saponins 1-4 exhibited significant cytotoxicity against human glioblastoma U251MG cells, but did not affect the growth of primary cultured human astrocytes.
从矮地茶（Ardisia pusilla A. DC.）全草中分离得到3个新的三萜皂苷3、4和5，以及2个已知皂苷，即紫金牛皂苷B（1）和紫金牛皂苷A（2）。通过广泛的光谱分析和化学证据阐明了它们的结构。化合物3是一种具有13,28 - 环氧齐墩果烷型苷元的六糖苷，而4和5都是与齐墩果 - 12 - 烯骨架相关的三萜四糖苷。皂苷1 - 4对人胶质母细胞瘤U251MG细胞表现出显著的细胞毒性，但不影响原代培养的人星形胶质细胞的生长。
