Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, United States.
Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN, United States.
Curr Opin Plant Biol. 2014 Feb;17:7-12. doi: 10.1016/j.pbi.2013.10.005. Epub 2013 Nov 5.
Organ development in multicellular organisms is dependent on the proper balance between cell proliferation and differentiation. In the Arabidopsis root apical meristem, meristem growth is the result of cell divisions in the proximal meristem and cell differentiation in the elongation and differentiation zones. Hormones, transcription factors and small peptides underpin the molecular mechanisms governing these processes. Computer modeling has aided our understanding of the dynamic interactions involved in stem cell maintenance and meristem activity. Here we review recent advances in our understanding of postembryonic root stem cell maintenance and control of meristem size.
多细胞生物的器官发育依赖于细胞增殖和分化之间的适当平衡。在拟南芥根顶端分生组织中,分生组织的生长是由近轴分生组织中的细胞分裂和伸长区和分化区中的细胞分化共同作用的结果。激素、转录因子和小肽是调控这些过程的分子机制的基础。计算机建模有助于我们理解干细胞维持和分生组织活性所涉及的动态相互作用。在这里,我们回顾了近年来在理解胚胎后根干细胞维持和分生组织大小控制方面的进展。