从蜂胶中分离出的咖啡酸苯乙酯对肿瘤细胞的选择性细胞毒性。
Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis.
作者信息
Grunberger D, Banerjee R, Eisinger K, Oltz E M, Efros L, Caldwell M, Estevez V, Nakanishi K
机构信息
Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
出版信息
Experientia. 1988 Mar 15;44(3):230-2. doi: 10.1007/BF01941717.
The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. Many important pharmaceutical properties have been ascribed to propolis, including anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Propolis extracts have provided an active component identified as caffeic acid phenethyl ester (CAPE), which was readily prepared in one step. Differential cytotoxicity has been observed in normal rat/human versus transformed rat/human melanoma and breast carcinoma cell lines in the presence of CAPE.
蜜蜂蜂巢产品蜂胶是一种用于治疗各种疾病的民间药物。蜂胶具有许多重要的药学特性，包括抗炎、抗病毒、免疫刺激和抗癌活性。蜂胶提取物含有一种活性成分，即咖啡酸苯乙酯（CAPE），它可以很容易地一步制备出来。在存在CAPE的情况下，已观察到正常大鼠/人类细胞与转化的大鼠/人类黑色素瘤和乳腺癌细胞系之间存在差异细胞毒性。
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