University Medical Center Goettingen, Institute for Cellular Biochemistry, Humboldtallee 23, Room 01.423, 37073 Goettingen, Germany.
Trends Mol Med. 2014 May;20(5):282-92. doi: 10.1016/j.molmed.2014.01.005. Epub 2014 Feb 5.
Mitochondria are undergoing a renaissance. The cellular power plant is now recognized as a key cellular signaling platform. The signals released by mitochondria are currently an area of intense research. A complex network is emerging involving metabolic intermediates, the roles of the mitochondrial unfolded protein response, and the interaction of mitochondria with other organelles and with the cellular autophagic system. Despite the diversity of the perturbations leading to mitochondrial diseases, some emerging trends are apparent. The long-held notion that mitochondrial diseases result from decreased mitochondrial energy output has been challenged by new data showing that mitochondrial pathological signaling can cause disease irrespective of the energy output. This review proposes a novel integrative view of mitochondrial signaling in physiology and disease.
线粒体正在经历复兴。这个细胞的“发电站”现在被认为是一个关键的细胞信号平台。线粒体释放的信号目前是一个研究热点。一个涉及代谢中间产物、线粒体未折叠蛋白反应的作用以及线粒体与其他细胞器和细胞自噬系统相互作用的复杂网络正在出现。尽管导致线粒体疾病的扰动因素多种多样，但一些新的趋势已经显现出来。长期以来，人们一直认为线粒体疾病是由于线粒体能量输出减少引起的，但新的数据表明，线粒体病理性信号传递可以导致疾病，而与能量输出无关，这一观点对这一观点提出了挑战。本文提出了一个线粒体信号在生理和疾病中的新的综合观点。
