Centre for Applied Biomedical Engineering Research, Department of Mechanical, Aeronautical and Biomedical Engineering and the Materials and Surface Science Institute University of Limerick, Limerick, Ireland.
Centre for Applied Biomedical Engineering Research, Department of Mechanical, Aeronautical and Biomedical Engineering and the Materials and Surface Science Institute University of Limerick, Limerick, Ireland.
J Biomech. 2014 Mar 3;47(4):793-804. doi: 10.1016/j.jbiomech.2014.01.017. Epub 2014 Jan 14.
The pathological changes associated with the development of atherosclerotic plaques within arterial vessels result in significant alterations to the mechanical properties of the diseased arterial wall. There are several methods available to characterise the mechanical behaviour of atherosclerotic plaque tissue, and it is the aim of this paper to review the use of uniaxial mechanical testing. In the case of atherosclerotic plaques, there are nine studies that employ uniaxial testing to characterise mechanical behaviour. A primary concern regarding this limited cohort of published studies is the wide range of testing techniques that are employed. These differing techniques have resulted in a large variance in the reported data making comparison of the mechanical behaviour of plaques from different vasculatures, and even the same vasculature, difficult and sometimes impossible. In order to address this issue, this paper proposes a more standardised protocol for uniaxial testing of diseased arterial tissue that allows for better comparisons and firmer conclusions to be drawn between studies. To develop such a protocol, this paper reviews the acquisition and storage of the tissue, the testing approaches, the post-processing techniques and the stress-strain measures employed by each of the nine studies. Future trends are also outlined to establish the role that uniaxial testing can play in the future of arterial plaque mechanical characterisation.
动脉血管中动脉粥样硬化斑块的发展所伴随的病理变化导致病变动脉壁的机械性能发生显著变化。有几种方法可用于描述动脉粥样硬化斑块组织的力学行为，本文旨在综述单轴力学测试的应用。在动脉粥样硬化斑块的情况下，有 9 项研究采用单轴测试来描述力学行为。对于这一组有限的已发表研究，一个主要关注点是所采用的测试技术范围广泛。这些不同的技术导致报告数据的差异很大，使得来自不同血管的斑块甚至同一血管的斑块的力学行为难以比较，有时甚至不可能进行比较。为了解决这个问题，本文提出了一种更标准化的用于患病动脉组织的单轴测试的方案，该方案允许更好地在研究之间进行比较，并得出更坚定的结论。为了制定这样的方案，本文综述了组织的获取和存储、测试方法、后处理技术以及 9 项研究中采用的应力-应变测量方法。还概述了未来的趋势，以确定单轴测试在动脉斑块力学特性未来研究中的作用。
