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CD2分子的T11(3)表位、绵羊红细胞与替代性T细胞激活途径。

The T11(3) epitope of the CD2 molecule, sheep erythrocytes, and the alternative T-cell activation pathway.

作者信息

Warren H S, McPhun V, Bezos A, Parish C R

机构信息

Cancer Research Unit, Woden Valley Hospital, Australian Capital Territory.

出版信息

Immunology. 1988 Feb;63(2):345-7.

PMID:2450837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454524/
Abstract

In this study, results are presented showing that the T11(3) epitope of the CD2 molecule is expressed on unfractionated peripheral blood mononuclear cells, resting T cells and activated T cells. T11(3) is not therefore, an activation-specific CD2 epitope. Sheep erythrocytes (SRC) which present a cell-surface ligand for CD2 could not effectively replace anti-T11(2) in initiating proliferation of resting T cells, stimulated by anti-T11(3). SRC with either of these anti-CD2 monoclonal antibodies did activate resting T cells, but proliferation required the presence of added IL-2.

摘要

在本研究中，结果表明CD2分子的T11(3)表位在未分级的外周血单个核细胞、静息T细胞和活化T细胞上表达。因此，T11(3)不是一个活化特异性的CD2表位。作为CD2细胞表面配体的绵羊红细胞（SRC）不能有效地替代抗T11(2)来启动由抗T11(3)刺激的静息T细胞的增殖。这两种抗CD2单克隆抗体中的任何一种与SRC确实能激活静息T细胞，但增殖需要添加白细胞介素-2。

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本文引用的文献

1
An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein.T 细胞活化的另一条途径：50kd T11 绵羊红细胞受体蛋白的功能作用。
Cell. 1984 Apr;36(4):897-906. doi: 10.1016/0092-8674(84)90039-4.
2
Preparation and characterization of human bone marrow-derived macrophages.人骨髓源性巨噬细胞的制备与表征
J Leukoc Biol. 1985 Oct;38(4):541-52. doi: 10.1002/jlb.38.4.541.
3
Phytohaemagglutinin activation of T cells through the sheep red blood cell receptor.植物血凝素通过绵羊红细胞受体激活T细胞。
Nature. 1985;313(6004):686-7. doi: 10.1038/313686a0.
4
Heterogeneity in the activation requirements of T cells stimulated by phytohaemagglutinin.植物血凝素刺激的T细胞激活需求的异质性。
Immunology. 1987 Jun;61(2):167-72.
5
Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand.通过CD2与其细胞表面配体结合实现T细胞的替代途径激活。
Nature. 1987;326(6110):298-301. doi: 10.1038/326298a0.
6
T11TS, the cell surface molecule binding to the "erythrocyte receptor" of T lymphocytes: cellular distribution, purification to homogeneity and biochemical properties.T11TS，一种与T淋巴细胞“红细胞受体”结合的细胞表面分子：细胞分布、纯化至均一性及生化特性
Eur J Immunol. 1986 Dec;16(12):1615-21. doi: 10.1002/eji.1830161223.
7
Anti-CD2 (sheep red blood cell receptor) monoclonal antibodies and T cell activation. I. Pairs of anti-T11.1 and T11.2 (CD2 subgroups) are strongly mitogenic for T cells in presence of 12-O-tetradecanoylphorbol 13-acetate.抗CD2（绵羊红细胞受体）单克隆抗体与T细胞活化。I. 在12-O-十四烷酰佛波醇-13-乙酸酯存在的情况下，抗T11.1和T11.2（CD2亚群）抗体对T细胞具有强烈的促有丝分裂作用。
Eur J Immunol. 1986 Sep;16(9):1063-8. doi: 10.1002/eji.1830160906.
8
T cell activation via CD2 [T, gp50]: the role of accessory cells in activating resting T cells via CD2.通过CD2 [T细胞，gp50]激活T细胞：辅助细胞在通过CD2激活静息T细胞中的作用。
J Immunol. 1986 Sep 1;137(5):1420-8.
9
The cell surface molecule recognized by the erythrocyte receptor of T lymphocytes. Identification and partial characterization using a monoclonal antibody.T淋巴细胞红细胞受体所识别的细胞表面分子。使用单克隆抗体进行鉴定及部分特性分析。
J Exp Med. 1985 Sep 1;162(3):890-901. doi: 10.1084/jem.162.3.890.
10
Functional consequences of sheep red blood cell rosetting for human T cells: gain of reactivity to mitogenic factors.绵羊红细胞玫瑰花结形成对人T细胞的功能影响：对促有丝分裂因子反应性的增强。
Eur J Immunol. 1978 Oct;8(10):693-6. doi: 10.1002/eji.1830081005.