CD2分子的T11(3)表位、绵羊红细胞与替代性T细胞激活途径。
The T11(3) epitope of the CD2 molecule, sheep erythrocytes, and the alternative T-cell activation pathway.
作者信息
Warren H S, McPhun V, Bezos A, Parish C R
机构信息
Cancer Research Unit, Woden Valley Hospital, Australian Capital Territory.
出版信息
Immunology. 1988 Feb;63(2):345-7.
Abstract
In this study, results are presented showing that the T11(3) epitope of the CD2 molecule is expressed on unfractionated peripheral blood mononuclear cells, resting T cells and activated T cells. T11(3) is not therefore, an activation-specific CD2 epitope. Sheep erythrocytes (SRC) which present a cell-surface ligand for CD2 could not effectively replace anti-T11(2) in initiating proliferation of resting T cells, stimulated by anti-T11(3). SRC with either of these anti-CD2 monoclonal antibodies did activate resting T cells, but proliferation required the presence of added IL-2.
摘要
在本研究中，结果表明CD2分子的T11(3)表位在未分级的外周血单个核细胞、静息T细胞和活化T细胞上表达。因此，T11(3)不是一个活化特异性的CD2表位。作为CD2细胞表面配体的绵羊红细胞（SRC）不能有效地替代抗T11(2)来启动由抗T11(3)刺激的静息T细胞的增殖。这两种抗CD2单克隆抗体中的任何一种与SRC确实能激活静息T细胞，但增殖需要添加白细胞介素-2。
相似文献
1
2
Sheep erythrocyte rosetting induces multiple alterations in T lymphocyte function: inhibition of T cell receptor activity and stimulation of T11/CD2.绵羊红细胞玫瑰花结形成诱导T淋巴细胞功能发生多种改变：抑制T细胞受体活性并刺激T11/CD2。
Cell Immunol. 1989 Oct 1;123(1):118-33. doi: 10.1016/0008-8749(89)90273-6.
3
Activation of human T lymphocytes through CD3 and CD2 (T11) with anti-CD3-coupled sheep erythrocytes.用抗CD3偶联的绵羊红细胞通过CD3和CD2（T11）激活人T淋巴细胞。
Scand J Immunol. 1988 May;27(5):609-13. doi: 10.1111/j.1365-3083.1988.tb02389.x.
4
Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand.通过CD2与其细胞表面配体结合实现T细胞的替代途径激活。
Nature. 1987;326(6110):298-301. doi: 10.1038/326298a0.
5
6
A unique epitope on the CD2 molecule defined by the monoclonal antibody 9-1: epitope-specific modulation of the E-rosette receptor and effects on T-cell functions.单克隆抗体9-1所界定的CD2分子上的独特表位：E花环受体的表位特异性调节及其对T细胞功能的影响
Hum Immunol. 1986 Dec;17(4):388-405. doi: 10.1016/0198-8859(86)90299-5.
7
Mapping the dextran sulfate binding site on CD2.
Immunol Cell Biol. 1990 Jun;68 ( Pt 3):199-205. doi: 10.1038/icb.1990.28.
8
Anti-CD2 (sheep red blood cell receptor) monoclonal antibodies and T cell activation. I. Pairs of anti-T11.1 and T11.2 (CD2 subgroups) are strongly mitogenic for T cells in presence of 12-O-tetradecanoylphorbol 13-acetate.抗CD2（绵羊红细胞受体）单克隆抗体与T细胞活化。I. 在12-O-十四烷酰佛波醇-13-乙酸酯存在的情况下，抗T11.1和T11.2（CD2亚群）抗体对T细胞具有强烈的促有丝分裂作用。
Eur J Immunol. 1986 Sep;16(9):1063-8. doi: 10.1002/eji.1830160906.
9
10
引用本文的文献
1
Altered production of tumour necrosis factors alpha and beta and interferon gamma by HIV-infected individuals.感染HIV的个体肿瘤坏死因子α和β以及干扰素γ的产生发生改变。
Clin Exp Immunol. 1991 Apr;84(1):109-15. doi: 10.1111/j.1365-2249.1991.tb08132.x.
本文引用的文献
1
An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein.T 细胞活化的另一条途径：50kd T11 绵羊红细胞受体蛋白的功能作用。
Cell. 1984 Apr;36(4):897-906. doi: 10.1016/0092-8674(84)90039-4.
2
Preparation and characterization of human bone marrow-derived macrophages.人骨髓源性巨噬细胞的制备与表征
J Leukoc Biol. 1985 Oct;38(4):541-52. doi: 10.1002/jlb.38.4.541.
3
Phytohaemagglutinin activation of T cells through the sheep red blood cell receptor.植物血凝素通过绵羊红细胞受体激活T细胞。
Nature. 1985;313(6004):686-7. doi: 10.1038/313686a0.
4
Heterogeneity in the activation requirements of T cells stimulated by phytohaemagglutinin.植物血凝素刺激的T细胞激活需求的异质性。
Immunology. 1987 Jun;61(2):167-72.
5
Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand.通过CD2与其细胞表面配体结合实现T细胞的替代途径激活。
Nature. 1987;326(6110):298-301. doi: 10.1038/326298a0.
6
T11TS, the cell surface molecule binding to the "erythrocyte receptor" of T lymphocytes: cellular distribution, purification to homogeneity and biochemical properties.T11TS，一种与T淋巴细胞“红细胞受体”结合的细胞表面分子：细胞分布、纯化至均一性及生化特性
Eur J Immunol. 1986 Dec;16(12):1615-21. doi: 10.1002/eji.1830161223.
7
Anti-CD2 (sheep red blood cell receptor) monoclonal antibodies and T cell activation. I. Pairs of anti-T11.1 and T11.2 (CD2 subgroups) are strongly mitogenic for T cells in presence of 12-O-tetradecanoylphorbol 13-acetate.抗CD2（绵羊红细胞受体）单克隆抗体与T细胞活化。I. 在12-O-十四烷酰佛波醇-13-乙酸酯存在的情况下，抗T11.1和T11.2（CD2亚群）抗体对T细胞具有强烈的促有丝分裂作用。
Eur J Immunol. 1986 Sep;16(9):1063-8. doi: 10.1002/eji.1830160906.
8
T cell activation via CD2 [T, gp50]: the role of accessory cells in activating resting T cells via CD2.通过CD2 [T细胞，gp50]激活T细胞：辅助细胞在通过CD2激活静息T细胞中的作用。
J Immunol. 1986 Sep 1;137(5):1420-8.
9
The cell surface molecule recognized by the erythrocyte receptor of T lymphocytes. Identification and partial characterization using a monoclonal antibody.T淋巴细胞红细胞受体所识别的细胞表面分子。使用单克隆抗体进行鉴定及部分特性分析。
J Exp Med. 1985 Sep 1;162(3):890-901. doi: 10.1084/jem.162.3.890.
10
Functional consequences of sheep red blood cell rosetting for human T cells: gain of reactivity to mitogenic factors.绵羊红细胞玫瑰花结形成对人T细胞的功能影响：对促有丝分裂因子反应性的增强。
Eur J Immunol. 1978 Oct;8(10):693-6. doi: 10.1002/eji.1830081005.
Zotero 插件