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一项评估急诊阑尾切除术后的星期几效应和结局的多中心队列研究。

A multicentre cohort study assessing day of week effect and outcome from emergency appendicectomy.

机构信息

West Midlands Research Collaborative, Queen Elizabeth Hospital, Birmingham, UK.

University College London, London, UK.

出版信息

BMJ Qual Saf. 2014 Sep;23(9):732-40. doi: 10.1136/bmjqs-2013-002290. Epub 2014 Feb 7.

DOI:10.1136/bmjqs-2013-002290
PMID:24508682
Abstract

BACKGROUND

There is evidence to suggest that patients undergoing treatment at weekends may be subject to different care processes and outcomes compared with weekdays. This study aimed to determine whether clinical outcomes from weekend appendicectomy are different from those performed on weekdays.

METHOD

Multicentre cohort study during May-June 2012 from 95 centres (89 within the UK). The primary outcome was the 30-day adverse event rate. Multilevel modelling was used to account for clustering within hospitals while adjusting for case mix to produce adjusted ORs and 95% CIs.

RESULTS

When compared with Monday, there were no significant differences for other days of the week considering 30-day adverse events in adjusted models. On Sunday, rates of simple appendicitis were highest, and rates of normal (OR 0.62, 95% CI 0.42 to 0.90) and complex appendicitis (OR 0.65, 95% CI 0.46 to 0.93) lowest. This was accompanied by a 43% lower likelihood in use of laparoscopy on Sunday (OR 0.47, 95% CI 0.32 to 0.69), accompanied by the lowest level of consultant presence for the week. When pooling weekends and weekdays, laparoscopy use remained less likely at the weekend (OR 0.68, 95% CI 0.55 to 0.83), with no significant difference for 30-day adverse event rate (OR 1.01, 95% CI 0.80 to 1.29).

CONCLUSIONS

This study found that weekend appendicectomy was not associated with increased 30-day adverse events. It cannot rule out smaller increases that may be shown by larger studies. It further illustrated that patients operated on at weekends were subject to different care processes, which may expose them to risk.

摘要

背景

有证据表明,与平日相比,周末接受治疗的患者可能会经历不同的治疗过程和结果。本研究旨在确定周末阑尾切除术的临床结果是否与平日不同。

方法

2012 年 5 月至 6 月期间,来自 95 个中心(英国 89 个)的多中心队列研究。主要结局是 30 天不良事件发生率。使用多水平模型来解释医院内的聚类现象,同时调整病例组合以产生调整后的比值比(OR)和 95%置信区间(CI)。

结果

在调整后的模型中,与周一相比,其他日子的 30 天不良事件发生率没有显著差异。在周日,单纯性阑尾炎的发生率最高,而正常(OR 0.62,95%CI 0.42 至 0.90)和复杂性阑尾炎(OR 0.65,95%CI 0.46 至 0.93)的发生率最低。这伴随着周日腹腔镜使用率降低了 43%(OR 0.47,95%CI 0.32 至 0.69),同时也是一周中顾问在场人数最少的一天。当将周末和工作日合并时,周末腹腔镜使用率仍然较低(OR 0.68,95%CI 0.55 至 0.83),30 天不良事件发生率无显著差异(OR 1.01,95%CI 0.80 至 1.29)。

结论

本研究发现周末阑尾切除术与 30 天不良事件增加无关。它不能排除更大的研究可能显示的较小的增加。它进一步说明了周末接受手术的患者接受了不同的护理过程,这可能使他们面临风险。

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