环氧化酶-2基因rs20417多态性与冠状动脉疾病风险：来自17621名受试者的证据。
The COX-2 rs20417 polymorphism and risk of coronary artery disease: evidence from 17,621 subjects.
作者信息
Wang Heng, Fu Yu, Liu Dong, Zhang Miao, Zhang Guoheng, Wu Wenbin, Yang Shijiang, Li Cunjiang, Zhang Hui
机构信息
Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China.
Department of Scientific Research and Education, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China.
出版信息
Heart Lung Circ. 2014 Jun;23(6):572-7. doi: 10.1016/j.hlc.2014.01.002. Epub 2014 Jan 22.
BACKGROUND
The Cyclooxygenase-2 (COX-2) rs20417 polymorphism has been implicated in coronary artery disease (CAD) risk, but individually published studies have shown inconsistent results. The aim of this study was to clarify the effects of COX-2 rs20417 polymorphism on CAD risk.
METHODS
A systematic literature search up to October 27, 2013 was carried out in PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases, and the references of retrieved articles were screened. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were analysed for co-dominant model (CC vs. GG), additive model (C vs. G), dominant model (CC+GC vs. GG), and recessive model (CC vs. GG+GC) to assess the association using fixed- or random-effect model.
RESULTS
We identified nine articles (10 case-control studies) that included 3,439 cases and 14,182 controls for the present meta-analysis. Significant association between COX-2 rs20417 polymorphism and risk of CAD was observed in co-dominant model (OR=0.64, 95% CI=0.43-0.95, p=0.026) and recessive model (OR=0.77, 95% CI=0.61-0.97, p=0.025). Moreover, in the subgroup analysis stratified by ethnicity, significant associations were observed in Asians (OR=0.28, 95% CI=0.13-0.61, p=0.001 for CC vs. GC+GG; OR=0.24, 95% CI=0.11-0.51, p<0.001 for CC vs. GG) but not in Caucasians.
CONCLUSIONS
These results suggest that COX-2 rs20417 polymorphism may contribute to CAD development, especially in Asians.
背景
环氧化酶-2（COX-2）基因rs20417多态性与冠状动脉疾病（CAD）风险有关，但个别发表的研究结果并不一致。本研究旨在阐明COX-2 rs20417多态性对CAD风险的影响。
方法
截至2013年10月27日，在PubMed、EMBASE和中国知网（CNKI）数据库中进行了系统的文献检索，并对检索文章的参考文献进行了筛选。采用固定效应模型或随机效应模型，分析共显性模型（CC与GG）、加性模型（C与G）、显性模型（CC + GC与GG）和隐性模型（CC与GG + GC）的粗比值比（OR）及95%置信区间（CI），以评估其关联性。
结果
我们纳入了9篇文章（10项病例对照研究），共3439例病例和14182例对照用于本荟萃分析。在共显性模型（OR = 0.64，95% CI = 0.43 - 0.95，p = 0.026）和隐性模型（OR = 0.77，95% CI = 0.61 - 0.97，p = 0.025）中，观察到COX-2 rs20417多态性与CAD风险之间存在显著关联。此外，在按种族分层的亚组分析中，亚洲人存在显著关联（CC与GC + GG比较，OR = 0.28，95% CI = 0.13 - 0.61，p = 0.001；CC与GG比较，OR = 0.24，95% CI = 0.11 - 0.51，p < 0.001），而高加索人中未观察到显著关联。
结论
这些结果表明，COX-2 rs20417多态性可能与CAD的发生有关，尤其是在亚洲人中。
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