Wahlin A, Grubb A, Holm J, Marklund S L
Department of Internal Medicine, University of Umeå, Sweden.
Acta Med Scand. 1988;223(3):263-7. doi: 10.1111/j.0954-6820.1988.tb15796.x.
We studied the influence of plasmapheresis on the plasma concentrations of proteins (IgG, IgA, beta 2-microglobulin) used for estimation of tumour cell mass in patients with multiple myeloma. Simultaneously, the effects of plasmapheresis on plasma concentrations of proteins (CRP, alpha 1-antitrypsin, haptoglobin) used for the assessment of inflammatory processes were studied. Also, changes in the plasma concentration of protein HC, a recently described protein occurring both as a free protein and as an IgA complex, were studied. The influence of plasmapheresis varied for the different proteins. The plasma levels of IgG, IgA, CRP, alpha 1-antitrypsin, and haptoglobin decreased during plasmapheresis. The simultaneous reduction of the level of protein HC was smaller than that of IgG, IgA and haptoglobin. The plasma concentration of beta 2-microglobulin did not decrease during plasmapheresis. The recovery rates of the proteins were found to be approximately inversely related to their molecular weights.
我们研究了血浆置换对用于评估多发性骨髓瘤患者肿瘤细胞量的蛋白质（IgG、IgA、β2-微球蛋白）血浆浓度的影响。同时，研究了血浆置换对用于评估炎症过程的蛋白质（CRP、α1-抗胰蛋白酶、触珠蛋白）血浆浓度的影响。此外，还研究了蛋白质HC（一种最近描述的既以游离蛋白形式又以IgA复合物形式存在的蛋白质）血浆浓度的变化。血浆置换对不同蛋白质的影响各不相同。血浆置换期间，IgG、IgA、CRP、α1-抗胰蛋白酶和触珠蛋白的血浆水平下降。蛋白质HC水平的同时降低幅度小于IgG、IgA和触珠蛋白。血浆置换期间β2-微球蛋白的血浆浓度没有下降。发现这些蛋白质的恢复率与其分子量大致呈负相关。
