Talstad I, Haugen H F
Scand J Clin Lab Invest. 1979 Oct;39(6):519-24. doi: 10.1080/00365517909108829.
The relationship between the erythrocyte sedimentation rate (ESR) and plasma proteins was studied within homogenous clinical material and in vitro models. In acute phase reactions, fibrinogen was the likely cause of the ESR-elevation, but there were significant associations between the ESR and the concentrations of alpha 1-antitrypsin, C3, haptoglobin and albumin. In chronic diseases, the ESR-elevation was probably caused by fibrinogen, mono- or polyclonal increase of IgG, IgA, IgM alone or in combinations. In multiple myeloma of the IgG and IgA subtypes, significant correlations were found between the ESR and the monoclonal proteins or between the ESR and the percentage of plasma cells in bone marrow. Model studies showed that the ESR increased linearly with the concentrations of fibrinogen or gammaglobulin (IgG) when these exceeded normal thresholds. The ESR was slightly decreased by increasing concentrations of albumin. Albumin had a synergistic effect on the ESR together with gamma-globulin, but not together with fibrinogen.
在同质临床材料和体外模型中研究了红细胞沉降率（ESR）与血浆蛋白之间的关系。在急性期反应中，纤维蛋白原可能是ESR升高的原因，但ESR与α1-抗胰蛋白酶、C3、触珠蛋白和白蛋白的浓度之间存在显著关联。在慢性疾病中，ESR升高可能是由纤维蛋白原、IgG、IgA、IgM单独或联合的单克隆或多克隆增加引起的。在IgG和IgA亚型的多发性骨髓瘤中，发现ESR与单克隆蛋白之间或ESR与骨髓中浆细胞百分比之间存在显著相关性。模型研究表明，当纤维蛋白原或γ球蛋白（IgG）浓度超过正常阈值时，ESR随其浓度呈线性增加。白蛋白浓度增加会使ESR略有下降。白蛋白与γ球蛋白一起对ESR有协同作用，但与纤维蛋白原一起则没有。
