Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; Prion and Health Office, Centers for Disease Control and Prevention, Atlanta, Georgia; Division of Preparedness and Emerging Infections, Centers for Disease Control and Prevention, Atlanta, Georgia.
Am J Trop Med Hyg. 2014 Mar;90(3):402-9. doi: 10.4269/ajtmh.13-0206. Epub 2014 Feb 10.
There are no published data on the economic burden for specific West Nile virus (WNV) clinical syndromes (i.e., fever, meningitis, encephalitis, and acute flaccid paralysis [AFP]). We estimated initial hospital and lost-productivity costs from 80 patients hospitalized with WNV disease in Colorado during 2003; 38 of these patients were followed for 5 years to determine long-term medical and lost-productivity costs. Initial costs were highest for patients with AFP (median $25,117; range $5,385-$283,381) and encephalitis (median $20,105; range $3,965-$324,167). Long-term costs were highest for patients with AFP (median $22,628; range $624-$439,945) and meningitis (median $10,556; range $0-$260,748). Extrapolating from this small cohort to national surveillance data, we estimated the total cumulative costs of reported WNV hospitalized cases from 1999 through 2012 to be $778 million (95% confidence interval $673 million-$1.01 billion). These estimates can be used in assessing the cost-effectiveness of interventions to prevent WNV disease.
尚无特定西尼罗河病毒（WNV）临床综合征（即发热、脑膜炎、脑炎和急性弛缓性麻痹[AFP]）的经济负担的发表数据。我们评估了 2003 年科罗拉多州 80 例 WNV 疾病住院患者的初始住院和生产力损失成本；其中 38 例患者随访 5 年以确定长期医疗和生产力损失成本。AFP（中位数 25117 美元；范围 5385-283381 美元）和脑炎（中位数 20105 美元；范围 3965-324167 美元）患者的初始成本最高。AFP（中位数 22628 美元；范围 624-439945 美元）和脑膜炎（中位数 10556 美元；范围 0-260748 美元）患者的长期成本最高。从这一小队列推断到全国监测数据，我们估计 1999 年至 2012 年报告的 WNV 住院病例的总累积成本为 7.78 亿美元（95%置信区间 6.73 亿至 10.10 亿美元）。这些估计可用于评估预防 WNV 疾病的干预措施的成本效益。
