自组装杂化纳米粒用于靶向递送至癌细胞的两种药物共递送。
Self-assembled hybrid nanoparticles for targeted co-delivery of two drugs into cancer cells.
机构信息
Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and Center for Research at the Interface of Bio/Nano, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA.
出版信息
Chem Commun (Camb). 2014 Mar 21;50(23):3103-5. doi: 10.1039/c3cc49003c.
Abstract
A therapeutic aptamer-lipid-poly(lactide-co-glycolic acid) hybrid nanoparticle-based drug delivery system was prepared and characterized. This system can co-deliver two different drugs with distinct solubility and different anticancer mechanisms to target cancer cells with high specificity and efficiency.
摘要
一种治疗性适体-脂质-聚（乳酸-共-乙醇酸）杂化纳米粒给药系统被制备并进行了表征。该系统可以同时递送两种具有不同溶解度和不同抗癌机制的不同药物，以高特异性和高效率靶向癌细胞。
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