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PLGA-DTX 纳米缀合物的合成及体外研究——口服癌症潜在药物传递载体。

Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer.

机构信息

CSIR-Indian Institute of Toxicological Research, Lucknow.

CSIR-National Physical Laboratory, New Delhi, India.

出版信息

Int J Nanomedicine. 2018 Mar 15;13(T-NANO 2014 Abstracts):67-69. doi: 10.2147/IJN.S124995. eCollection 2018.

DOI:10.2147/IJN.S124995
PMID:29593398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5863638/
Abstract

Advances in nanotechnology have led to the design of multifunctional nanoparticles capable of cellular imaging, targeted drug delivery, and diagnostics for early cancer detection. We synthesized poly(lactic--glycolic acid) nanoparticles encapsulating a model radiosensitizing drug docetaxel accomplishing localized in situ delivery of the sensitizer to the tumor site. The synthesized nanoparticles have been characterized for their physicochemical properties. The in vitro cytotoxicity of drug-loaded nanoparticles has been studied on human tongue carcinoma cell line SCC-9 (ATCC-CRL-1629).

摘要

纳米技术的进步使得设计多功能纳米粒子成为可能，这些纳米粒子能够进行细胞成像、靶向药物传递以及用于早期癌症检测的诊断。我们合成了包裹模型放射增敏药物多西紫杉醇的聚（乳酸-乙醇酸）纳米粒子，实现了增敏剂在肿瘤部位的局部原位递送。已经对合成的纳米粒子进行了物理化学性质的表征。在体外，已经在人舌鳞癌细胞系 SCC-9（ATCC-CRL-1629）上研究了载药纳米粒子的细胞毒性。

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引用本文的文献

[1]
Advanced drug delivery systems for oral squamous cell carcinoma: a comprehensive review of nanotechnology-based and other innovative approaches.

Front Drug Deliv. 2025-6-27

[2]
Advancing oral cancer care: nanomaterial-driven diagnostic and therapeutic innovations.

Cell Biol Toxicol. 2025-5-23

[3]
Cytotoxicity of Nanocarrier-Based Drug Delivery in Oral Cancer Therapy: A Systematic Review and Meta-Analysis.

Cancer Control. 2025

[4]
Nano-Drug Delivery Systems in Oral Cancer Therapy: Recent Developments and Prospective.

Pharmaceutics. 2023-12-19

[5]
Docetaxel-Loaded Methoxy poly(ethylene glycol)-poly (L-lactic Acid) Nanoparticles for Breast Cancer: Synthesis, Characterization, Method Validation, and Cytotoxicity.

Pharmaceuticals (Basel). 2023-11-13

[6]
Nanoencapsulation of Docetaxel Induces Concurrent Apoptosis and Necroptosis in Human Oral Cancer Cells (SCC-9) via TNF-α/RIP1/RIP3 Pathway.

Indian J Clin Biochem. 2023-7

[7]
The Anti-Tumor and Immunomodulatory Effects of PLGA-Based Docetaxel Nanoparticles in Lung Cancer: The Potential Involvement of Necroptotic Cell Death through Reactive Oxygen Species and Calcium Build-Up.

Vaccines (Basel). 2022-10-26

[8]
Advanced Polymeric Nanoagents for Oral Cancer Theranostics: A Mini Review.

Front Chem. 2022-6-14

[9]
Mucoadhesive Nanocarriers as a Promising Strategy to Enhance Intracellular Delivery against Oral Cavity Carcinoma.

Pharmaceutics. 2022-4-5

[10]
Nanomedicine for increasing the oral bioavailability of cancer treatments.

J Nanobiotechnology. 2021-10-30

本文引用的文献

[1]
Prognoses for head and neck cancers in Europe diagnosed in 1995-1999: a population-based study.

Ann Oncol. 2010-6-29

[2]
Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery.

Mol Cancer Ther. 2006-8

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