CSIR-Indian Institute of Toxicological Research, Lucknow.
CSIR-National Physical Laboratory, New Delhi, India.
Int J Nanomedicine. 2018 Mar 15;13(T-NANO 2014 Abstracts):67-69. doi: 10.2147/IJN.S124995. eCollection 2018.
Advances in nanotechnology have led to the design of multifunctional nanoparticles capable of cellular imaging, targeted drug delivery, and diagnostics for early cancer detection. We synthesized poly(lactic--glycolic acid) nanoparticles encapsulating a model radiosensitizing drug docetaxel accomplishing localized in situ delivery of the sensitizer to the tumor site. The synthesized nanoparticles have been characterized for their physicochemical properties. The in vitro cytotoxicity of drug-loaded nanoparticles has been studied on human tongue carcinoma cell line SCC-9 (ATCC-CRL-1629).
纳米技术的进步使得设计多功能纳米粒子成为可能，这些纳米粒子能够进行细胞成像、靶向药物传递以及用于早期癌症检测的诊断。我们合成了包裹模型放射增敏药物多西紫杉醇的聚（乳酸-乙醇酸）纳米粒子，实现了增敏剂在肿瘤部位的局部原位递送。已经对合成的纳米粒子进行了物理化学性质的表征。在体外，已经在人舌鳞癌细胞系 SCC-9（ATCC-CRL-1629）上研究了载药纳米粒子的细胞毒性。
