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Toxins (Basel). 2014 Feb 10;6(2):608-23. doi: 10.3390/toxins6020608.
Evidence for the role of oxidative stress in the pathophysiology of mycotoxin-related illness is increasing. The glutathione antioxidant and detoxification systems play a major role in the antioxidant function of cells. Exposure to mycotoxins in humans requires the production of glutathione on an "as needed" basis. Research suggests that mycotoxins can decrease the formation of glutathione due to decreased gene expression of the enzymes needed to form glutathione. Mycotoxin-related compromise of glutathione production can result in an excess of oxidative stress that leads to tissue damage and systemic illness. The review discusses the mechanisms by which mycotoxin-related deficiency of glutathione may lead to both acute and chronic illnesses.
越来越多的证据表明，氧化应激在霉菌毒素相关疾病的病理生理学中起作用。谷胱甘肽抗氧化和解毒系统在细胞的抗氧化功能中起着重要作用。人类接触霉菌毒素需要“按需”产生谷胱甘肽。研究表明，霉菌毒素会由于形成谷胱甘肽所需的酶的基因表达减少而减少谷胱甘肽的形成。与霉菌毒素有关的谷胱甘肽生成受损会导致氧化应激过度，从而导致组织损伤和全身性疾病。本文讨论了与霉菌毒素相关的谷胱甘肽缺乏可能导致急性和慢性疾病的机制。
