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地塞米松诱导猪卵巢囊肿形成过程中胆碱能神经支配模式的变化。

Changes in the cholinergic innervation pattern of porcine ovaries with cysts induced by dexamethasone administration.

机构信息

Division of Reproductive Biology, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Tuwima 10, 10-748, Olsztyn, Poland,

出版信息

J Mol Neurosci. 2014 Sep;54(1):10-9. doi: 10.1007/s12031-014-0239-1. Epub 2014 Feb 13.

DOI:10.1007/s12031-014-0239-1
PMID:24519145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4125811/
Abstract

We revealed earlier that induction of ovarian cysts in gilts by dexamethasone phosphate disodium salt (DXM) administration from the follicular phase of the estrous cycle (EC) changed the cholinergic innervation of the gonad. In the present study, the innervation of porcine ovaries by vesicular acetylcholine transporter (VAChT)-, neuronal nitric oxide synthase (nNOS)-, vasoactive intestinal peptide (VIP)- and somatostatin (SOM)-immunoreactive (IR) fibres, after induction of cystic changes from the middle luteal phase of the EC, was determined. The cystic changes were induced by DXM injections from days 7 to 21 of the EC, and 11 days later, the ovaries were collected. In the cystic ovaries, VAChT-, nNOS- and SOM-IR fibres were found around cysts and small tertiary follicles; nNOS-IR and also VAChT-IR fibres were observed near secondary follicles and veins; and VAChT- and nNOS-IR fibres were not found around cortical arteries. The number of VIP-IR fibres increased near the cysts and within the ground plexus, while the number of VAChT-IR fibres decreased within the medullar part of this structure. Thus, our study showed changes in the cholinergic innervation pattern of the porcine cystic ovaries induced from the middle phase of the cycle and confirmed that cystic ovary innervation depends partly on the phase of the EC in which the induction of cysts was started.

摘要

我们之前曾揭示，在发情周期（EC）的卵泡期用磷酸地塞米松二钠盐（DXM）处理诱导母猪卵巢囊肿会改变卵巢的胆碱能神经支配。在本研究中，在 EC 的黄体中期开始诱导囊肿形成后，确定了猪卵巢中囊泡乙酰胆碱转运蛋白（VAChT）-、神经元型一氧化氮合酶（nNOS）-、血管活性肠肽（VIP）-和生长抑素（SOM）-免疫反应（IR）纤维的支配。通过在 EC 的第 7 天至第 21 天注射 DXM 来诱导囊肿变化，11 天后收集卵巢。在囊性卵巢中，VAChT-、nNOS-和 SOM-IR 纤维被发现在囊肿和小三级卵泡周围；nNOS-IR 和 VAChT-IR 纤维也被观察到在次级卵泡和静脉附近；而在皮质动脉周围没有发现 VAChT-和 nNOS-IR 纤维。在囊肿附近和地幔丛内 VIP-IR 纤维的数量增加，而在该结构的髓质部分 VAChT-IR 纤维的数量减少。因此，我们的研究表明，从中期开始诱导囊肿形成后，猪囊性卵巢的胆碱能神经支配模式发生了变化，并证实了囊性卵巢的神经支配部分取决于开始诱导囊肿的 EC 阶段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/b9435319de93/12031_2014_239_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/dd183caa13c0/12031_2014_239_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/a951895455ab/12031_2014_239_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/a77069976a87/12031_2014_239_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/66d01ba5a417/12031_2014_239_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/be78792bddc4/12031_2014_239_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/b9435319de93/12031_2014_239_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/dd183caa13c0/12031_2014_239_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/a951895455ab/12031_2014_239_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/a77069976a87/12031_2014_239_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/66d01ba5a417/12031_2014_239_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/be78792bddc4/12031_2014_239_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a29f/4125811/b9435319de93/12031_2014_239_Fig6_HTML.jpg

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