Evans T W, Dixon C M, Clarke B, Conradson T B, Barnes P J
Department of Clinical Pharmacology, Brompton Hospital, London.
Br J Clin Pharmacol. 1988 Feb;25(2):273-5. doi: 10.1111/j.1365-2125.1988.tb03302.x.
The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurred with either peptide, but diastolic BP fell significantly with SP infusion. SP caused bronchodilation and NKA bronchoconstriction. NKA and SP have differing physiological roles and may activate different receptor populations.
在六名正常受试者中比较了静脉注射神经激肽A（NKA）和P物质（SP）对气道和心血管系统的影响。SP和NKA均可使皮肤温度（SkT）和心率（HR）升高，但SP的作用分别比NKA强6倍和20倍。两种肽均未引起收缩压（BP）变化，但输注SP后舒张压显著下降。SP引起支气管扩张，而NKA引起支气管收缩。NKA和SP具有不同的生理作用，可能激活不同的受体群体。
