Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore).
Angew Chem Int Ed Engl. 2014 Mar 3;53(10):2722-6. doi: 10.1002/anie.201309198. Epub 2014 Feb 7.
The rhodium(III)-catalyzed ortho C-H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation.
铑(III)催化的非电子活化芳基的邻位 C-H 炔基化反应被揭示。该过程具有合成功能化炔烃的直接而高效的方案，代表了将高价碘试剂与铑(III)催化相结合的首例。值得注意的是，该反应在室温下进行，可耐受多种官能团，更重要的是，对单炔基化具有高选择性。
