泰国门诊患者抑郁障碍的基线特征：泰国情感障碍研究的结果。
Baseline characteristics of depressive disorders in Thai outpatients: findings from the Thai Study of Affective Disorders.
机构信息
Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
出版信息
Neuropsychiatr Dis Treat. 2014 Jan 31;10:217-23. doi: 10.2147/NDT.S56680. eCollection 2014.
BACKGROUND
The Thai Study of Affective Disorders was a tertiary hospital-based cohort study developed to identify treatment outcomes among depressed patients and the variables involved. In this study, we examined the baseline characteristics of these depressed patients.
METHODS
Patients were investigated at eleven psychiatric outpatient clinics at tertiary hospitals for the presence of unipolar depressive disorders, as diagnosed by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The severity of any depression found was measured using the Clinical Global Impression and 17-item Hamilton Depression Rating Scale (HAMD) clinician-rated tools, with the Thai Depression Inventory (a self-rated instrument) administered alongside them. Sociodemographic and psychosocial variables were collected, and quality of life was also captured using the health-related quality of life (SF-36v2), EuroQoL (EQ-5D), and visual analog scale (EQ VAS) tools.
RESULTS
A total of 371 outpatients suffering new or recurrent episodes were recruited. The mean age of the group was 45.7±15.9 (range 18-83) years, and 75% of the group was female. In terms of diagnosis, 88% had major depressive disorder, 12% had dysthymic disorder, and 50% had a combination of both major depressive disorder and dysthymic disorder. The mean (standard deviation) scores for the HAMD, Clinical Global Impression, and Thai Depression Inventory were 24.2±6.4, 4.47±1.1, and 51.51±0.2, respectively. Sixty-two percent had suicidal tendencies, while 11% had a family history of depression. Of the major depressive disorder cases, 61% had experienced a first episode. The SF-36v2 component scores ranged from 25 to 56, while the mean (standard deviation) of the EQ-5D was 0.50±0.22 and that of the EQ VAS was 53.79±21.3.
CONCLUSION
This study provides an overview of the sociodemographic and psychosocial characteristics of patients with new or recurrent episodes of unipolar depressive disorders.
背景
泰国情感障碍研究是一项基于三级医院的队列研究，旨在确定抑郁患者的治疗结果和相关变量。在这项研究中，我们检查了这些抑郁患者的基线特征。
方法
在三级医院的十一家精神病门诊诊所，通过《精神障碍诊断与统计手册》第四版（DSM-IV）对单相抑郁障碍患者进行检查。使用临床总体印象量表（CGI）和 17 项汉密尔顿抑郁量表（HAMD）医生评定工具评估发现的任何抑郁的严重程度，同时还使用泰国抑郁量表（一种自评工具）进行评估。收集社会人口统计学和心理社会变量，使用健康相关生活质量量表（SF-36v2）、欧洲五维健康量表（EQ-5D）和视觉模拟量表（EQ VAS）评估生活质量。
结果
共招募了 371 名新发病例或复发的门诊患者。该组的平均年龄为 45.7±15.9（范围 18-83）岁，75%的患者为女性。在诊断方面，88%的患者患有重度抑郁症，12%的患者患有恶劣心境障碍，50%的患者同时患有重度抑郁症和恶劣心境障碍。HAMD、CGI 和泰国抑郁量表的平均（标准差）得分为 24.2±6.4、4.47±1.1 和 51.51±0.2。62%的患者有自杀倾向，11%的患者有抑郁家族史。在重度抑郁症患者中，61%的患者为首次发作。SF-36v2 组成部分的评分范围为 25-56，EQ-5D 的平均（标准差）为 0.50±0.22，EQ VAS 的平均（标准差）为 53.79±21.3。
结论
本研究提供了单相抑郁障碍新发病例或复发患者的社会人口统计学和心理社会特征概述。
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