Jiang Jia-Hao, Gao Qiang, Ke Ai-Wu, Yu Yao, Shi Guo-Ming, Fan Jia, Zhou Jian, Huang Xiao-Wu
Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Ministry of Education, Shanghai 200032, P.R. China.
Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Ministry of Education, Shanghai 200032, P.R. China ; Shanghai Key Laboratory of Organ Transplantation, Shanghai 200032, P.R. China.
Oncol Lett. 2014 Mar;7(3):641-646. doi: 10.3892/ol.2014.1809. Epub 2014 Jan 16.
Studies have highlighted important features of the nucleocytoplasmic transport of mRNAs and proteins. Nuclear RNA export factor 3 (NXF3) is a member of the nuclear RNA export factor family that plays a role in mediating the export of cellular mRNA from the nucleus to the cytoplasm for translation. However, little is known about the clinical significance of NXF3 in human tumors. To evaluate the prognostic significance of NXF3 in hepatocellular carcinoma (HCC), the expression levels of NXF3 in a cohort of 112 patients with primary HCC who had undergone hepatectomy for histologically confirmed HCC were assessed by immunohistochemistry. It was identified that the expression levels of NXF3 were higher in the primary HCC tissues compared with those in paired peritumoral liver tissues. The overexpression of NXF3 in the HCC tissues was correlated with decreased survival time [hazard ratio (HR) = 1.954, 95% confidence interval (CI) = 1.034-3.695, P=0.039] and earlier tumor recurrence (HR = 2.101, 95% CI = 1.186-3.722, P=0.011) in postoperative patients with HCC. Notably, overexpression of NXF3 was correlated with a poor survival time and increased recurrence following HCC resection in male patients (P=0.020 and P=0.007, respectively) but not in female patients (P=0.916 and P=0.821, respectively). In conclusion, the findings provide evidence that implicates NXF3 as a prospective predictor of HCC prognosis as well as a potential therapeutic target for cancer treatment.
研究突出了mRNA和蛋白质核质转运的重要特征。核RNA输出因子3（NXF3）是核RNA输出因子家族的成员，在介导细胞mRNA从细胞核输出到细胞质进行翻译过程中发挥作用。然而，关于NXF3在人类肿瘤中的临床意义知之甚少。为了评估NXF3在肝细胞癌（HCC）中的预后意义，通过免疫组织化学评估了112例经组织学确诊为HCC并接受肝切除术的原发性HCC患者队列中NXF3的表达水平。结果发现，与配对的癌旁肝组织相比，原发性HCC组织中NXF3的表达水平更高。HCC组织中NXF3的过表达与术后HCC患者的生存时间缩短相关[风险比（HR）=1.954，95%置信区间（CI）=1.034 - 3.695，P = 0.039]以及肿瘤复发更早（HR = 2.101，95%CI = 1.186 - 3.722，P = 0.011）。值得注意的是，NXF3的过表达与男性患者HCC切除术后的不良生存时间和复发增加相关（分别为P = 0.020和P = 0.007），而与女性患者无关（分别为P = 0.916和P = 0.821）。总之，这些发现提供了证据，表明NXF3是HCC预后的一个前瞻性预测指标以及癌症治疗的一个潜在治疗靶点。
