Faculty of Medicine & Life Sciences, Hasselt University, Campus Diepenbeek, Martelarenlaan 42, 3500 Hasselt, Belgium.
Biomark Med. 2014;8(2):297-306. doi: 10.2217/bmm.13.122.
Through their tumor-promoting and/or tumor-suppressive properties, cytokines can influence progression of cancer. We systematically reviewed the current literature on the prognostic value of the circulating cytokines IL-1α/β, IL-6, IL-8, IL-10, IL-12, TNF-α, TGF-β and IFN-γ to predict overall and disease-free survival in any type of cancer patients. PubMed was systematically searched and based on eligibility assessment using our five criteria of the Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK) checklist, six unique studies were reviewed. Elevated IL-6 and IL-10 levels seem independently associated with worse prognosis in terms of overall and disease-free survival. The prognostic value of IL-1α/β, IL-8, IL-12, TNF-α, TGF-β and IFN-γ could not be demonstrated. The small number of selected studies underlines the need for large well-designed prospective studies, using the REMARK checklist as a guideline, to determine which cytokines have prognostic value on survival in cancer patients.
通过其促进肿瘤和/或抑制肿瘤的特性，细胞因子可以影响癌症的进展。我们系统地回顾了目前关于循环细胞因子 IL-1α/β、IL-6、IL-8、IL-10、IL-12、TNF-α、TGF-β 和 IFN-γ 的预后价值的文献，以预测任何类型癌症患者的总生存率和无病生存率。我们系统地检索了 PubMed，并根据我们的肿瘤标志物预后研究报告建议 (REMARK) 清单的五个标准进行了资格评估，共审查了六项独特的研究。升高的 IL-6 和 IL-10 水平似乎与总生存率和无病生存率较差独立相关。IL-1α/β、IL-8、IL-12、TNF-α、TGF-β 和 IFN-γ 的预后价值尚无法证明。选择的研究数量较少，强调需要进行大型精心设计的前瞻性研究，使用 REMARK 清单作为指导，以确定哪些细胞因子对癌症患者的生存具有预后价值。
