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马来西亚发现的新型 HIV-1 CRF53_01B 的基因组序列。

Genome sequences of a novel HIV-1 CRF53_01B identified in Malaysia.

机构信息

Centre of Excellence for Research in AIDS, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

J Virol. 2012 Oct;86(20):11398-9. doi: 10.1128/JVI.01932-12.

DOI:10.1128/JVI.01932-12
PMID:22997419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3457147/
Abstract

A novel HIV-1 genotype designated CRF53_01B was recently characterized from three epidemiologically unrelated persons in Malaysia. Here we announced three recently isolated full-length genomes of CRF53_01B, which is likely to be phylogenetically linked to CRF33_01B, circulating widely in Southeast Asia. The genome sequences may contribute to HIV-1 molecular surveillance and future vaccine development in the region.

摘要

一种新型 HIV-1 基因型被命名为 CRF53_01B,最近在马来西亚的三个无关联的个体中被发现。在此,我们报道了三种最近分离到的 CRF53_01B 全长基因组,该基因型可能与广泛流行于东南亚的 CRF33_01B 存在系统进化上的联系。该基因组序列可能有助于该地区的 HIV-1 分子监测和未来的疫苗研发。

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Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates.通过对三株1型艾滋病毒分离株进行全基因组分析在新加坡鉴定出新的CRF51_01B
AIDS Res Hum Retroviruses. 2012 May;28(5):527-30. doi: 10.1089/aid.2011.0177. Epub 2011 Sep 23.
3
Identification of a novel second-generation circulating recombinant form (CRF48_01B) in Malaysia: a descendant of the previously identified CRF33_01B.在马来西亚鉴定出一种新型第二代循环重组形式(CRF48_01B):先前鉴定出的 CRF33_01B 的后代。
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Estimating the date of origin of an HIV-1 circulating recombinant form.估计HIV-1循环重组形式的起源日期。
Virology. 2009 Apr 25;387(1):229-34. doi: 10.1016/j.virol.2009.02.020. Epub 2009 Mar 9.
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Identification of CRF34_01B, a second circulating recombinant form unrelated to and more complex than CRF15_01B, among injecting drug users in northern Thailand.在泰国北部的注射吸毒者中鉴定出CRF34_01B,这是一种与CRF15_01B无关且比其更复杂的第二种循环重组形式。
AIDS Res Hum Retroviruses. 2007 Jun;23(6):829-33. doi: 10.1089/aid.2006.0300.
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