马来西亚新型 HIV-1 循环重组型 54_01B 的基因组序列。
Genome sequence of a novel HIV-1 circulating recombinant form 54_01B from Malaysia.
机构信息
Centre of Excellence for Research in AIDS, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
出版信息
J Virol. 2012 Oct;86(20):11405-6. doi: 10.1128/JVI.01949-12.
Abstract
We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B' and CRF01_AE, with identical recombination breakpoints observed in the gag, pol, and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B' and CRF01_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia.
摘要
我们在此报告首例从马来西亚三个不同风险群体的无关联个体中分离到的新型 HIV-1 循环重组型 54_01B（CRF54_01B）。这些最近采集的重组病毒显示出复杂的基因组结构，由亲本亚型 B'和 CRF01_AE 组成，在 gag、pol 和 vif 基因中观察到相同的重组断点。这一发现突出了涉及亚型 B'和 CRF01_AE 谱系的新的亚型间重组的持续活跃产生和传播，并表明该新型 CRF 有可能在东南亚不同风险群体之间传播 HIV-1。
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