Kim Hye One, Kim Jin Hye, Chung Bo Young, Choi Min Gyu, Park Chun Wook
Department of Dermatology, College of Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
Exp Dermatol. 2014 Apr;23(4):278-81. doi: 10.1111/exd.12350. Epub 2014 Mar 4.
Polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are major environmental pollutants, and their effects on the human body critically depend on the aryl hydrocarbon receptor (AhR). The aim of this study was to evaluate the significance of the AhR and its ligands in chronic inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis. Expression of AhR-related mRNA was increased in lesional skin from patients with AD and psoriasis compared to those of normal skin from healthy controls. The AhR and aryl hydrocarbon receptor nuclear translocator were colocalized in the nuclei of keratinocytes at the lower epidermis of psoriatic lesions, which suggested activation of the AhR pathway. After treatment of normal human epidermal keratinocytes with TCDD or PCBs, IL-6 and IL-8 production were increased. The results of this study suggest that AhR is highly expressed in the acute lesional skin of patients with AD and psoriasis, and the AhR pathway is activated especially in psoriasis.
多氯联苯（PCBs）和2,3,7,8-四氯二苯并对二恶英（TCDD）是主要的环境污染物，它们对人体的影响严重依赖芳烃受体（AhR）。本研究的目的是评估AhR及其配体在特应性皮炎（AD）和银屑病等慢性炎症性皮肤病中的意义。与健康对照者的正常皮肤相比，AD和银屑病患者皮损皮肤中AhR相关mRNA的表达增加。AhR和芳烃受体核转运蛋白在银屑病皮损下表皮角质形成细胞的细胞核中共定位，这表明AhR途径被激活。用TCDD或PCBs处理正常人表皮角质形成细胞后，白细胞介素-6（IL-6）和白细胞介素-8（IL-8）的产生增加。本研究结果表明，AhR在AD和银屑病患者的急性皮损皮肤中高表达，尤其是在银屑病中AhR途径被激活。
